2025 publications
2020 publications
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2020 publications
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Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice |
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Singular role for T-BET+CXCR3+ regulatory T cells in protection from autoimmune diabetes. |
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Aire Inhibits the Generation of a Perinatal Population of Interleukin-17A-Producing gammadeltaT Cells to Promote Immunologic Tolerance. |
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IL-33, Imprimatur of Adipocyte Thermogenesis. |
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Network pharmacology of JAK inhibitors. |
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Tissue Tregs. |
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Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells. |
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Unstable FoxP3+ T regulatory cells in NZW mice. |
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Parsing the Interferon Transcriptional Network and Its Disease Associations. | |
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Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3. |
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Immunological contributions to adipose tissue homeostasis. DiSpirito JR, Mathis D. Semin Immunol. 2015 Sep;27(5):315-21. Review. |
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Rapid, high efficiency isolation of pancreatic ß-cells. |
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Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells. |
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Aire controls gene expression in the thymic epithelium with ordered stochasticity. |
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Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells. |
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Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3. |
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A pharmacogenetic study implicates SLC9a9 in multiple sclerosis disease activity. |
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Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice |
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ImmVar project: Insights and design considerations for future studies of "healthy" immune variation. |
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Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance. |
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Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients. |
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Population dynamics of islet-infiltrating cells in autoimmune diabetes. |
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Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: Age, diet, and PPARγ effects. |
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Genomic responses to inflammation in mouse models mimic humans: we concur, apples to oranges comparisons won't do. |
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Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells. |
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Single-cell mass cytometry of TCR signaling: Amplification of small initial differences results in low ERK activation in NOD mice. |
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Variation and Genetic Control of Gene Expression in Primary Immunocytes across Inbred Mouse Strains. |
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Intersection of population variation and autoimmunity genetics in human T cell activation. |
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Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature. |
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Type 1 Diabetes in NOD Mice Unaffected by Mast Cell Deficiency. |
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Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes. |
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Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut. |
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Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses. |
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Interindividual variation in human T regulatory cells. |
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Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch |
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An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription. |
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Fluorescent Exendin-4 Derivatives for Pancreatic β-Cell Analysis. |
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A special population of regulatory T cells potentiates muscle repair. |
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Restoration of the Unfolded Protein Response in Pancreatic β Cells Protects Mice Against Type 1 Diabetes.
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A gut feeling about arthritis. |
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Soluble factors secreted by T-cells promote β-cell proliferation. |
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Regulatory T cells in nonlymphoid tissues. |
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Differential Response of Regulatory and Conventional CD4+ Lymphocytes to CD3 Engagement: Clues to a Possible Mechanism of Anti-CD3 Action? Li L, Nishio J, van Maurik A, Mathis D, Benoist C. J Immunol. 2013 Oct 1;191(7):3694-704 |
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Immunological goings-on in visceral adipose tissue. |
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Differential splicing across immune system lineages. |
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Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2. |
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The transcriptional landscape of αβ T cell differentiation. |
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Conservation and divergence in the transcriptional programs of the human and mouse immune systems. |
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Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance. |
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Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells. |
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Cre-Mediated Cell Ablation Contests Mast Cell Contribution in Models of Antibody- and T Cell-Mediated Autoimmunity. |
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Microbiota and autoimmune disease: the hosted self. |
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Accurate measurement of pancreatic islet {beta}-cell mass using a second-generation fluorescent exendin-4 analog. |
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Tissular T(regs): A unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism. |
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Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. |
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Genome-Wide and Species-Wide Dissection of the Genetics of Arthritis Severity in Heterogeneous Stock Mice. |
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A cluster of coregulated genes determines TGF-{beta}-induced regulatory T-cell (Treg) dysfunction in NOD mice. |
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Immunometabolism: an emerging frontier. |
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Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells. |
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Transcriptomes of the B and T Lineages Compared by Multiplatform Microarray Profiling. |
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Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients. |
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The Type 1 Diabetes PhysioLab Platform: a validated physiologically based mathematical model of pathogenesis in the non-obese diabetic mouse.. |
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A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus. |
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Stability of the Regulatory T Cell Lineage in vivo. |
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Commercially available outbred mice for genome-wide association studies. |
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Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints. |
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Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells. |
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Global relevance of Aire binding to hypomethylated lysine-4 of histone-3. |
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Deficiency of CXCR2, but not other chemokine receptors, attenuates a murine model of autoantibody-mediated arthritis. |
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A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice. |
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Quantitative phosphoproteomic analysis of T cell receptor signaling in diabetes prone and resistant mice. |
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Genomic definition of multiple ex vivo regulatory T cell subphenotypes. |
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Neutrophils in a mouse model of autoantibody-mediated arthritis: Critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1. |
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Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis. |
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Aire's Partners in the Molecular Control of Immunological Tolerance. Abramson J, Giraud M, Benoist C, Mathis D. |
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Levees of immunological tolerance. Mathis D, Benoist C. Nat Immunol. 2010 Jan;11(1):3-6 Review. |
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IL-17-producing T cells can augment autoantibody-induced arthritis. |
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How Punctual Ablation of Regulatory T Cells Unleashes an Autoimmune Lesion within the Pancreatic Islets. |
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The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. |
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A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis. |
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Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function. |
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Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. |
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Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. |
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Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity. |
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Autoimmune Diabetes. Diane Mathis and Jason Gaglia. |
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Aire. |
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The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors. |
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Retinoic Acid Enhances Foxp3 Induction Indirectly by Relieving Inhibition from CD4(+)CD44(hi) Cells. |
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Genetic Inversion in Mast Cell-Deficient Wsh Mice Interrupts Corin and Manifests as Hematopoietic and Cardiac Aberrancy. |
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Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. |
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The variable immunological self: Genetic variation and nongenetic noise in Aire-regulated transcription. |
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Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated.. |
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The Immunological Genome Project: networks of gene expression in immune cells. |
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Transcriptional impact of Aire varies with cell type. |
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B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients. |
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A broad analysis of IL1 polymorphism and rheumatoid arthritis. |
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Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the DPT1 trial. |
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The K/BxN Arthritis Model. |
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The AKT-mTOR
axis regulates de novo differentiation of CD4+Foxp3+ cells. |
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Foxp3 Transcription-Factor-Dependent
and -Independent Regulation of the Regulatory T Cell Transcriptional
Signature. |
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Enhanced
thymic selection of FoxP3+ regulatory T cells in the NOD mouse
model of
autoimmune
diabetes. |
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Danger-free autoimmune disease
in Aire-deficient mice. |
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Lymphotoxin Pathway and
Aire Influences on Thymic Medullary Epithelial Cells Are Unconnected. |
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Proliferative
arrest and rapid turnover of thymic epithelial cells expressing
Aire. |
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Sustained antigen
presentation can promote an immunogenic T cell response, like
dendritic cell
activation. |
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Circulating C3 is necessary and sufficient for induction of autoantibody-mediated arthritis in a mouse model. |
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The
K/BxN mouse model of inflammatory arthritis:
Theory and Practice. |
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TCR-based
lineage tracing: no evidence for conversion of conventional into
regulatory T cells in response to a natural
self-antigen in pancreatic islets. |
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Inflammatory
arthritis can be reined in by CpG-induced DC NK cell cross
talk. |
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A decade of AIRE. |
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Adaptation
of TCR Repertoires to Self-Peptides in Regulatory and Nonregulatory
CD4+ T Cells. |
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The same genomic region conditions clonal deletion and clonal deviation to the CD8{alpha}{alpha} and regulatory T cell lineages in NOD versus C57BL/6 mice. |
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Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity. |
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Lack of Foxp3 function and expression in the thymic epithelium. |
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Regulatory T-cell differentiation: Committed to control: a precocious choice? |
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Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1. |
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Where
FoxP3-dependent regulatory T cells impinge on the development of inflammatory
arthritis. |
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T(reg)
cells: guardians for life. |
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Altered
natural killer cells in type 1 diabetic patients. |
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Signatures
of strong population differentiation shape extended haplotypes
across
the human CD28, CTLA4, and ICOS costimulatory genes. |
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Modeling
CTLA4-linked autoimmunity with RNA interference in mice. |
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FOXP3
controls regulatory T cell function through cooperation with
NFAT. |
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Gene expression
microarrays: glimpses of the immunological genome. |
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A plaidoyer
for 'systems immunology'. |
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A shared gene-expression
signature in innate-like lymphocytes. |
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Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. Nishio J, Gaglia JL, Turvey SE, Campbell C, Benoist C, Mathis D. Science. 2006 Mar 24;311(5768):1775-8. |
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Induction of tolerance
in arthritogenic B cells with receptors of differing affinity
for self-antigen. |
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Memory T and memory
B cells share a transcriptional program of self-renewal with long-term
hematopoietic stem cells. |
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Particularities
of the vasculature can promote the organ specificity of autoimmune
attack. |
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Endocrine
self and gut non-self intersect in the pancreatic lymph nodes. |
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Where CD4+CD25+ T reg
cells impinge on autoimmune diabetes. |
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Cathepsin L is essential
for onset of autoimmune diabetes in NOD mice. |
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How
defects in central tolerance impinge on a deficiency in regulatory
T cells. |
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Modifier
loci condition autoimmunity provoked by Aire deficiency. |
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Lymphocyte
tolerance: central is central. |
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Variation
in IL-1{beta} gene expression is a major determinant of genetic
differences
in arthritis aggressivity in mice. |
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The
Cellular Mechanism of Aire Control of T Cell Tolerance. |
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Noninvasive
imaging of pancreatic inflammation and its reversal in type 1 diabetes. |
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Interleukin-4
can be a key positive regulator of inflammatory arthritis. |
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Antigen persistence
is required throughout the expansion phase of a CD4+ T cell
response. |
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Chromosomal clustering of genes controlled by the aire transcription
factor. |
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AIRE and
APECED: molecular insights into an
autoimmune disease. |
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Defective
Central Tolerance Induction in NOD Mice: Genomics and Genetics. |
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Green
t(r) cells. |
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Back
to central tolerance. |
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Good riddance: Thymocyte clonal deletion
prevents autoimmunity. |
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Number of T reg cells
that differentiate does not increase upon encounter of agonist ligand
on thymic epithelial
cells. |
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Lack of requirement
of osteopontin for inflammation, bone erosion, and cartilage
damage in
the K/BxN model of autoantibody-mediated arthritis. |
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Fas deficiency prevents
type 1 diabetes by inducing hyporesponsiveness in islet beta-cell-reactive
T-cells. |
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Natural killer cells distinguish innocuous
and destructive forms of pancreatic islet autoimmunity. |
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Progression
to islet destruction in a cyclophosphamide-induced transgenic model:
a microarray overview. |
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Imaging inflammation of the pancreatic islets in type 1 diabetes. |
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The
role of antibodies in mouse models of rheumatoid
arthritis, and relevance to human disease. |
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Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells. Yamagata T, Mathis D, Benoist C.Nat Immunol. 2004 Jun;5(6):597-605. |
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CD4+CD25+ T regulatory cells dependent on ICOS promote regulation
of effector cells in the prediabetic lesion. |
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The molecular
program indued in T cells undergoing homeostatic proliferation. |
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Immunology
at Asilomar: from molecules to mice. |
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Physiological beta cell death triggers priming of self-reactive T cells
by dendritic cells in a type-1 diabetes model. |
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aradoxical dampening of anti-islet self-reactivity
but promotion of diabetes by OX40 ligand. |
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Susceptible
MHC alleles, not background genes, select an autoimmune T cell
reactivity. |
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T-cell
compartments of prediabetic NOD mice. |
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Low prevalence of antibodies to glucose-6-phosphate isomerase
in patients with rheumatoid arthritis and a spectrum of other chronic
autoimmune
disorders. |
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Mast
cells in autoimmune disease. |
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Projection
of an immunological self shadow within the thymus by the aire protein. |
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Cytokine requirements for acute and Basal homeostatic proliferation
of naive and
memory CD8+ T cells. |
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Critical roles for interleukin 1 and tumor necrosis factor alpha
in antibody-induced arthritis. |
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How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease. |
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Arthritis critically dependent on innate immune
system players |
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Arthritogenic monoclonal antibodies from K/BxN mice. |
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TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. |
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B-Cell Death During
Progression to Diabetes. |
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Autoimmunity provoked
by infection: how good is the case for T cell epitope mimicry? |
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Genetic influences on
the end-stage effector phase of arthritis. |
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T lymphocytes need IL-7
but not IL-4 or IL-6 to survive in vivo. |
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Damage control, rather
than unresponsivenesss, effected by protective DX5+ T cells in autoimmune
diabetes. |
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How much TCR does a T
cell need? |
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A molecular chart of
thymocyte positive selection. |
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The shaping of the T cell repertoire. |
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A cassette
vector for high-level reporter expression driven by a hybrid invariant
chain promoter in transgenic mice. |
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A revival
of the B cell paradigm for rheumatoid arthritis pathogenesis? |
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Role of
the forkhead transcription family member, FKHR, in thymocyte differentiation. |
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Pinpointing
when T cell costimulatory receptor CTLA-4 must be engaged to dampen
diabetogenic T cells. |
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Tetracycline-controllable
selection of CD4(+) T cells: half-life and survival signals in the
absence of major
histocompatibility complex class II molecules. |
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Mice lacking
all conventional MHC class II genes. |
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Arthritis provoked by linked T and B cell recognition of a glycolytic
enzyme. |
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The arthritogenic T cell
receptor and its ligand in a model of spontaneous arthritis. |
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Different modes of pathogenesis
in T-cell-dependent autoimmunity: clues from two TCR transgenic systems. |
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Amino acids specifying MHC class preference in TCR V alpha 2
regions. |
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From systemic
T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. |
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T-cell development: a
new marker of differentiation state. |
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Initiation of autoimmune
diabetes by developmentally regulated presentation of islet cell antigens
in the pancreatic lymph nodes. |
pp |
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An influence of CD5 on the selection of CD4-lineage T cells. Chan S, Waltzinger C, Tarakhovsky A, Benoist C, Mathis D. Eur J Immunol. 1999 Sep;29(9):2916-22. |
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Cellular and molecular
changes accompanying the progression from insulitis to diabetes. |
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Positive selection of
thymocytes induced by gene transfer: MHC class II-mediated selection
of CD8-lineage cells. |
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Inhibition of thymocyte
positive selection by natural MHC:peptide ligands. |
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Autoimmunity. The
pathogen connection. |
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CD4/CD8 lineage
commitment: matching fate with competence. |
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CD4+ T cell responses in mice
lacking MHC class II molecules specifically on B cells. |
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Mice lacking the transcription
factor CIITA--a second look. |
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Visualization of CD4/CD8 T
cell commitment. |
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Major histocompatibility complex
class II molecules can protect from diabetes by positively selecting
T cells with additional specificities. |
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Cytotoxic T lymphocyte-associated
antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. |
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Interleukin-4 deficiency does
not exacerbate disease in NOD mice. |
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The phenotype of H-2M-deficient mice is dependent on the MHC class II molecules expressed. Wolf PR, Tourne S, Miyazaki T, Benoist C, Mathis D, Ploegh HL. Eur J Immunol. 1998 Sep;28(9):2605-18. |
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Autoimmune diabetes.
Retrovirus as trigger, precipitator or marker? |
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Selection for survival? |
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Cell death mediators
in autoimmune diabetes--no shortage of suspects. |
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Positive selection of T cells: fastidious or promiscuous? |
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Interferon-gamma impacts at
multiple points during the progression of autoimmune diabetes. |
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Targeted complementation of
MHC class II deficiency by intrathymic delivery of recombinant
adenoviruses. |
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Selection of a broad repertoire
of CD4+ T cells in H-2Ma0/0 mice. |
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Functionality of major
histocompatibility complex class II molecules in mice doubly
deficient for invariant
chain and H-2M complexes. |
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Positive selection of T cells
induced by viral delivery of neopeptides to the thymus. |
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Genetic control of diabetes
progression. |
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Amino Acid residues
on the I-Ak alpha-chain required for the binding and stability of
two antigenic peptides. |
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The role of CD8+ T
cells in the initiation of insulin-dependent diabetes mellitus. |
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Checkpoints in the
progression of autoimmune disease: lessons from diabetes models. |
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Mice lacking H2-M complexes,
enigmatic elements of the MHC class II peptide-loading pathway. |
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The immunosuppressant
15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality
between preT and preB cell differentiation. |
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Independent modes of
natural killing distinguished in mice lacking Lag3. |
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LAG-3 is not responsible
for selecting T helper cells in CD4-deficient mice. |
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Biosynthesis of major
histocompatibility complex molecules and generation of T cells in Ii
TAP1 double-mutant mice. |
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Organ-specific disease
provoked by systemic autoreactivity. |
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Antiviral immune responses
of mice lacking MHC class II or its associated invariant chain. |
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Mice lacking
terminal deoxynucleotidyl transferase: adult mice with a fetal
antigen receptor
repertoire. |
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Efficient immune responses
in mice lacking N-region diversity.
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The influence of invariant
chain on the positive selection of single T cell receptor specificities. |
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Helper cell subsets in
insulin-dependent diabetes. |
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CD1-restricted CD4+ T
cells in major histocompatibility complex class II-deficient mice. |
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Cassette vectors directing
expression of T cell receptor genes in transgenic mice. |
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The influence of positive
selection on RAG expression in thymocytes. |
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T-cell co-receptors.
The end of a frustrating search. |
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MHC control of the naive TCR alpha-chain repertoire. Merkenschlager M, Benoist C, Mathis D. J Immunol. 1994 Oct 1;153(7):3005-13. |
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Role of coreceptors in
positive selection and lineage commitment. |
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More efficient
positive selection of thymocytes in mice lacking terminal deoxynucleotidyl
transferase. |
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Dominant
negative analogs of NF-YA. |
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In favor of
the selective model of positive selection. |
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Evidence for a single-niche
model of positive selection. |
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Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain. Bodmer H, Viville S, Benoist C, Mathis D. Science. 1994 Mar 4;263(5151):1284-6. |
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The immune
system of mice lacking conventional MHC class II molecules. |
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Graft rejection across
transgene-encoded MHC class II molecules. |
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Defects in antigen presentation
of mutant influenza haemagglutinins are reversed by mutations in the
MHC class II molecule. |
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Delineation of antigen
contact residues on an MHC class II molecule |
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Co-evolution from yeast
to mouse: cDNA cloning of NF-Y subunits. |
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MHC-linked protection
from diabetes dissociated from clonal deletion of T cells. |
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Regulation of MHC class
II gene expression: the Y box and the nuclear factor that binds to
it, NF-Y. |
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Regulation of major
histocompatibility complex class-II genes: X, Y and other letters
of the alphabet. |
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Superantigens interact
with MHC class II molecules outside the antigen groove. |
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Functional consequences
of overexpressed Ia antigens in Akalpha/Akbeta transgenic mice. |
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Sperm cells
as vectors for transferring DNA into mouse eggs: a breakthrough for
immunologists? |
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T-cell recognition of
superantigens: inside or outside the groove? |
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Positive and negative
selection of the T cell reperoire in MHC class II
transgenic mice. |
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Antigen/MHC-specific
T cells are preferentially exported from the thymus in the presence
of their MHC ligand. |
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Positive selection of
the T cell repertoire: where and when does it occur? |
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Transgenic mice: new
systems for studying the function of MHC class II molecules. In "H-2
antigens: genes, molecules and function." |
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Properties of a CCAAT box-binding protein. |
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A multiplicity of CCAAT
box-binding proteins. |
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Conserved major histocompatibility
complex class II boxes--X and Y--are transcriptional control elements
and specifically bind nuclear proteins. |
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The regulation of Ia
gene transcription. |
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Functional sites on Ia
molecules: a molecular dissection of A alpha immunogenicity. |
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The assignment of chain
specificities for anti-Ia monoclonal antibodies using L cell transfectants. |
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Altered I-J phenotype
in E alpha transgenic mice. |
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E alpha u and E beta
u chain association: where lies the anomaly? |
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Transgenic mice: "New
Wave" immunogenetics. |
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Correcting an immune-response
deficiency by creating E alpha gene transgenic mice. |
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A molecular
basis for the Ia.2 and Ia.19 antigenic determinants. |
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Inbred and wild mice
carry identical deletions in their E alpha MHC genes. |
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