Tissue regulatory T cells: regulatory chameleons
Muñoz-Rojas A, Mathis D. Nat Rev Immuno. 2021 Mar 26.

Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations
Zemmour D, Charbonnier LM, Leon J, Six E, Keles S, Delville M, Benamar M, Baris S, Zuber J, Chen K, Neven B, Garcia-Lloret MI, Ruemmele FM, Brugnara C, Cerf-Bensussan N, Rieux-Laucat F, Cavazzana M, André I, Chatila TA, Mathis D, Benoist C. Nat Immunol. 2021 May;22(5):607-619.

PPARγ marks splenic precursors of multiple nonlymphoid-tissue Treg compartments.
Li C, Muñoz-Rojas A, Wang G, Mann A, Benoist C, Mathis D.
PNAS March 30, 2021 118 (13) e202519711.

Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut.
Yan Y, Ramanan D, Rozenberg M, McGovern K, Rastelli D, Vijaykumar B, Yaghi O, Voisin T, Mosaheb M, Chiu I, Itzkovitz S, Rao M, Mathis D, Benoist C.
Immunity. 2021 Mar 9;54(3):499-513.e5.

Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes.
Kiner E, Willie E, Vijaykumar B, Chowdhary K, Schmutz H, Chandler J, Schnell A, Thakore PI, LeGros G, Mostafavi S, Mathis D, Benoist C; Immunological Genome Project Consortium. Nat Immunol. 2021 Feb;22(2):216-228.

A combination of cyclophosphamide, interleukin-2 allow CD4+ T cells converted to Tregs to control scurfy syndrome.
Delville M, Bellier F, Leon J, Klifa R, Lizot S, Vinçon H, Sobrino S, Thouenon R, Marchal A, Garrigue A, Olivre J, Charbonnier S, Lagresle-Peyrou C, Amendola M, Schambach A, Gross DA, Lamarthée B, Benoist C, Zuber J, André I, Cavazzana M, Six E. Blood. 2021 Feb 5:blood.2020009187.

 

2020 publications

Profound Treg perturbations correlate with COVID-19 severity.
Galván-Peña S, Leon J, Chowdhary K, Michelson DA, Vijaykumar B, Yang L, Magnuson A, Manickas-Hill Z, Piechocka-Trocha A, Worrall DP, Hall KE, Ghebremichael M, Walker BD, Li J, Yu XG, Mathis D, Benoist C. bioRxiv. 2020 Dec 11:2020.12.11.416180.

Deep learning of immune cell differentiation.
Maslova A, Ramirez RN, Ma K, Schmutz H, Wang C, Fox C, Ng B, Benoist C, Mostafavi S; Immunological Genome Project.
Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25655-25666.

Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo.
Fernandes RA, Li C, Wang G, Yang X, Savvides CS, Glassman CR, Dong S, Luxenberg E, Sibener LV, Birnbaum ME, Benoist C, Mathis D, Garcia KC. Elife. 2020 Aug 10;9:e58463.

pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise.
Reddy A, Bozi L, Yaghi O, Mills E, Xiao H, Nicholson H, Paschini M, Paulo J, Garrity R, Laznik-Bogoslavski D, Ferreira J, Carl C, Sjøberg K, Wojtaszewski J, Jeppesen J, Kiens B, Gygi S, A, Richter E, DianeMathis D, Chouchani E. Cell 183, 1–14. Epub 2020 Sept 17.

An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint.
Ramanan D, Sefik E, Galván-Peña S, Wu M, Yang L, Yang Z, Kostic A, Golovkina TV, Kasper DL, Mathis D, Benoist C. Cell. 2020 Jun 11;181(6):1276-1290.e13.

CD4+ teff cell heterogeneity: the perspective from single-cell transcriptomics.
Zemmour D, Kiner E, Benoist C. Curr Opin Immunol. 2020 Apr;63:61-67. Review.

Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance.
Huoh YS, Wu B, Park S, Yang D, Bansal K, Greenwald E, Wong WP, Mathis D, Hur S. Nat Commun. 2020 Apr 2;11(1):1625.

Visceral adipose tissue Tregs and the cells that nurture them.
Li C, Spallanzani RG, Mathis D. Immunol Rev. 2020 May;295(1):114-125 Review.

Sex-specific adipose tissue imprinting of regulatory T cells.
Vasanthakumar A, Chisanga D, Blume J, Gloury R, Britt K, Henstridge DC, Zhan Y, Torres SV, Liene S, Collins N, Cao E, Sidwell T, Li C, Spallanzani RG, Liao Y, Beavis PA, Gebhardt T, Trevaskis N, Nutt SL, Zajac JD, Davey RA, Febbraio MA, Mathis D, Shi W, Kallies A. Nature. 2020 Feb 26.

Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle
Wang K, Yaghi O, Spallanzani RG, Chen X, Zemmour D, Lai N, Chiu I, Benoist C and Mathis D. Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5402-5408. Epub 2020 Feb 26.

γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis.
Hu B, Jin C, Zeng X, Resch JM, Jedrychowski MP, Yang Z, Desai BN, Banks AS, Lowell BB, Mathis D, Spiegelman BM. Nature. 2020 Feb;578(7796):610-614.

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis.
Song X, Sun X, Oh SF, Wu M, Zhang Y, Zheng W, Geva-Zatorsky N, Jupp R, Mathis D, Benoist C, Kasper DL. Nature. 2020 Jan;577(7790):410-415.

Developmental and cellular age direct conversion of CD4+ T cells into RORγ+ or Helios+ colon Treg cells.
Pratama A, Schnell A, Mathis D, Benoist C. J Exp Med. 2020 Jan 6;217(1).

 
 

2019 publications

T cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscle.
Cho J, Kuswanto W, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2019 Dec 10.

The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability.
Ronin E, Lubrano di Ricco M, Vallion R, Divoux J, Kwon HK, Grégoire S, Collares D, Rouers A, Baud V, Benoist C, Salomon BL. Front Immunol. 2019 Oct 30;10:2487. eCollection 2019.

PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice.
Syed I, de Celis MFR, Mohan JF, Moraes-Vieira PM, Vijayakumar A, Nelson AT, Siegel D, Saghatelian A, Mathis D, Kahn BB. J Clin Invest. 2019 Aug 5;130. eCollection 2019 Aug 5.

Distinct immunocyte-promoting and adipocyte-generating stromal components coordinate adipose tissue immune and metabolic tenors.
Spallanzani RG, Zemmour D, Xiao T, Jayewickreme T, Li C, Bryce PJ, Benoist C, Mathis D. Sci Immunol. 2019 May 3;4(35).

T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33.
Tuncel J, Benoist C, Mathis D. J Exp Med. 2019 Apr 15.[Epub ahead of print]

 

Methods of Isolation and Analysis of TREG Immune Infiltrates from Injured and Dystrophic Skeletal Muscle.
Burzyn D, Wagers A, Mathis D, Cerletti M. Methods Mol Biol. 2019;1899:229-237.

 

Organismal immunometabolism: advances in both directions.
Mathis D. Nat Rev Immunol. 2019 Feb;19(2):83-84.

 

The cis-Regulatory Atlas of the Mouse Immune System.
Yoshida H, Lareau CA, Ramirez RN, Rose SA, Maier B, Wroblewska A, Desland F, Chudnovskiy A, Mortha A, Dominguez C, Tellier J, Kim E, Dwyer D, Shinton S, Nabekura T, Qi Y, Yu B, Robinette M, Kim KW, Wagers A, Rhoads A, Nutt SL, Brown BD, Mostafavi S, Buenrostro JD, Benoist C. Immunological Genome Project. 2019, Cell 176, 897–912

2018 publications

Age-related tumor growth in mice is related to integrin α 4 in CD8+ T cells.
Oh J, Magnuson A, Benoist C, Pittet MJ, Weissleder R. JCI Insight. 2018 Nov 2;3(21).

Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types.
Magnuson AM, Kiner E, Ergun A, Park JS, Asinovski N, Ortiz-Lopez A, Kilcoyne A, Paoluzzi-Tomada E, Weissleder R, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10672-E10681.

   

Genetic determinants of co-accessible chromatin regions in activated T cells across humans.
Gate RE, Cheng CS, Aiden AP, Siba A, Tabaka M, Lituiev D, Machol I, Gordon MG, Subramaniam M, Shamim M, Hougen KL, Wortman I, Huang SC, Durand NC, Feng T, De Jager PL, Chang HY, Aiden EL, Benoist C, Beer MA, Ye CJ, Regev A. Nat Genet. 2018 Aug;50(8):1140-1150.

TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype.
Li C, DiSpirito JR, Zemmour D, Spallanzani RG, Kuswanto W, Benoist C, Mathis D. Cell. 2018 Jul 12;174(2):285-299.e12.

Treg cells limit IFN-γ production to control macrophage accrual and phenotype during skeletal muscle regeneration.
Panduro M, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):E2585-E2593.

Molecular diversification of regulatory T cells in nonlymphoid tissues.
DiSpirito JR, Zemmour D, Ramanan D, Cho J, Zilionis R, Klein AM, Benoist C, Mathis D. Sci Immunol. 2018 Sep 14;3(27).

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR.
Zemmour D, Zilionis R, Kiner E, Klein AM, Mathis D, Benoist C. Nat Immunol. 2018 Mar;19(3):291-301. Erratum in: Nat Immunol. 2018 May 3;:.

FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes.
Kwon HK, Chen HM, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E253-E262.

2017 publications

Different molecular complexes that mediate transcriptional induction and repression by FoxP3.
Kwon HK, Chen HM, Mathis D, Benoist C. Nat Immunol. 2017 Nov;18(11):1238-1248.

Imaging the emergence and natural progression of spontaneous autoimmune diabetes.
Mohan JF, Kohler RH, Hill JA, Weissleder R, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7776-E7785.

Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny.
Silverman M, Kua L, Tanca A, Pala M, Palomba A, Tanes C, Bittinger K, Uzzau S, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9671-9676.

The Human Cell Atlas
Aviv Regev, Sarah Teichmann, Eric S. Lander, Ido Amit, Christophe Benoist, Ewan Birney, Bernd Bodenmiller, Peter Campbell, Piero Carninci, Menna Clatworthy, Hans Clevers, Bart Deplancke, Ian Dunham, James Eberwine, Roland Eils, Wolfgang Enard, Andrew Farmer, Lars Fugger, Berthold Gottgens, Nir Hacohen, Muzlifah Haniffa, Martin Hemberg, Seung K. Kim, Paul Klenerman, Arnold Kriegstein, Ed Lein, Sten Linnarsson, Joakim Lundeberg, Partha Majumder, John Marioni, Miriam Merad, Musa Mhlanga, Martijn Nawijn, Mihai Netea, Garry Nolan, Dana Pe'er, Anthony Philipakis, Chris P. Ponting, Stephen R. Quake, Wolf Reik, Orit Rozenblatt-Rosen, Joshua R. Sanes, Rahul Satija, Ton Shumacher, Alex K. Shalek, Ehud Shapiro, Padmanee Sharma, Jay Shin, Oliver Stegle, Michael Stratton, Michael J. T. Stubbington, Alexander van Oudenaarden, Allon Wagner, Fiona M. Watt, Jonathan S. Weissman, Barbara Wold, Ramnik J. Xavier, Nir Yosef
bioRxiv 12120

bioRxiv
12120

Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity.
Zemmour D, Pratama A, Loughhead SM, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3472-E3480.

An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk.
Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM, Mathis D, Benoist C. Cell. 2017 Mar 9;168(6):1135-1148.e12. doi: 10.1016/j.cell.2017.02.009.

T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow.
Glatman Zaretsky A, Konradt C, Depis F, Wing JB, Goenka R, Atria DG, Silver JS, Cho S, Wolf AI, Quinn WJ, Engiles JB, Brown DC, Beiting D, Erikson J, Allman D, Cancro MP, Sakaguchi S, Lu LF, Benoist CO, Hunter CA. Cell Rep. 2017 Feb 21;18(8):1906-1916.

Mining the Human Gut Microbiota for Immunomodulatory Organisms.
Geva-Zatorsky N, Sefik E, Kua L, Pasman L, Tan TG, Ortiz-Lopez A, Yanortsang TB, Yang L, Jupp R, Mathis D, Benoist C, Kasper DL. Cell. 2017 Feb 23;168(5):928-943.e11.

The transcriptional regulator Aire binds to and activates super-enhancers.
Bansal K, Yoshida H, Benoist C, Mathis D. Nat Immunol. 2017 Mar;18(3):263-273. 

2016 publications

Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice
Tan T, Sefik E, Geva-Zatorsky N, Kua L, Naskar D, Teng F, Pasman L, Ortiz-Lopez A, Jupp R, Wu HJ, Kasper D, Benoist C, Mathis D. Proc Natl Acad Sci U S A.2016 Dec 13;113(50):E8141-E8150.

Singular role for T-BET+CXCR3+ regulatory T cells in protection from autoimmune diabetes.
Tan TG, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14103-14108.

Aire Inhibits the Generation of a Perinatal Population of Interleukin-17A-Producing gammadeltaT Cells to Promote Immunologic Tolerance.
Fujikado N, Mann A, Bansa K, Romito K, Ferre E, Rosenzweig S,  Lionakis M, Benoist C, Mathis D. Immunity. 2016 Nov 15;45(5):999–1012

IL-33, Imprimatur of Adipocyte Thermogenesis.
Mathis D. Cell. 2016 Aug 11;166(4):794-5.

Network pharmacology of JAK inhibitors.
Moodley D, Yoshida H, Mostafavi S, Asinovski N, Ortiz-Lopez A, Symanowicz P, Telliez JB, Hegen M, Clark JD, Mathis D, Benoist C.
Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9852-7.

Tissue Tregs.
Panduro M, Benoist C, Mathis D. Annu Rev Immunol. 2016 May 20;34:609-33.

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells.
Kuswanto W, Burzyn D, Panduro M, Wang KK, Jang YC, Wagers AJ, Benoist C, Mathis D. Immunity. 2016 Feb 16;44(2):355-67.

Unstable FoxP3+ T regulatory cells in NZW mice.
Dépis F, Kwon HK, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1345-50

2015 publications

Parsing the Interferon Transcriptional Network and Its Disease Associations.
Mostafavi S, Yoshida H, Moodley D, LeBoité H, Rothamel K, Raj T, Ye CJ, Chevrier N, Zhang SY, Feng T, Lee M, Casanova JL, Clark JD, Hegen M, Telliez JB, Hacohen N, De Jager PL, Regev A, Mathis D, Benoist C; Immunological Genome Project Consortium.
Cell. 2016 Jan 28;164(3):564-78.

Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3.
Yan D, Farache J, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14942-7. Erratum in: Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):E256.

Immunological contributions to adipose tissue homeostasis.
DiSpirito JR, Mathis D. Semin Immunol. 2015 Sep;27(5):315-21. Review.
 

Rapid, high efficiency isolation of pancreatic ß-cells.
Clardy SM, Mohan JF, Vinegoni C, Keliher EJ, Iwamoto Y, Benoist C, Mathis D, Weissleder R. Sci Rep. 2015 Sep 2;5:13681.

Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells.
Sefik E, Geva-Zatorsky N, Oh S, Konnikova L, Zemmour D, McGuire AM, Burzyn D, Ortiz-Lopez A, Lobera M, Yang J, Ghosh S, Earl A, Snapper SB, Jupp R, Kasper D, Mathis D, Benoist C. Science. 2015 Aug 28;349(6251):993-7.

Aire controls gene expression in the thymic epithelium with ordered stochasticity.
Meredith M, Zemmour D, Mathis D, Benoist C. Nat Immunol. 2015 Sep;16(9):942-9.

Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells.
Yoshida H, Bansal K, Schaefer U, Chapman T, Rioja I, Proekt I, Anderson MS, Prinjha RK, Tarakhovsky A, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4448-57.

Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.
Goettel JA, Biswas S, Lexmond WS, Yeste A, Passerini L,Patel B, Yang S, Sun J, Ouahed J, Shouval DS, McCann KJ, Horwitz BH, Mathis D, Milford EL, Notarangelo LD, Roncarolo M-G, Fiebiger E, Marasco WA, Bacchetta R, Quintana F, Pai S-Y, Klein C, Muise AM, Snapper SB. Blood. 2015 Jun 18;125(25):3886-95.

A pharmacogenetic study implicates SLC9a9 in multiple sclerosis disease activity.
Esposito F, Sorosina M, Ottoboni L, Lim ET, Replogle JM, Raj T, Brambilla P, Liberatore G, Guaschino C, Romeo M, Pertel T, Stankiewicz JM, Martinelli V, Rodegher M, Weiner HL, Brassat D, Benoist C, Patsopoulos NA, Comi G, Elyaman W, Martinelli Boneschi F, De Jager PL.
Ann Neurol. 2015 Jul;78(1):115-27.

Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice
Kolodin D, van Panhuys N, Li C, Magnuson AM, Cipolletta D, Miller CM, Wagers A, Germain RN, Benoist C, Mathis D. Cell Metab.2015 Apr 7;21(4):543-57

ImmVar project: Insights and design considerations for future studies of "healthy" immune variation.
De Jager PL, Hacohen N, Mathis D, Regev A, Stranger BE, Benoist C. Semin Immunol. 2015 Mar 25. pii: S1044-5323(15)00011-1. Review.

Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance.
Yang S, Fujikado N, Kolodin D, Benoist C, Mathis D. Science. 2015 May 1;348(6234):589-94.

Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients.
Gaglia JL, Harisinghani M, Aganj I, Wojtkiewicz GR, Hedgire S, Benoist C, Mathis D, Weissleder R. Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2139-44.

Population dynamics of islet-infiltrating cells in autoimmune diabetes.
Magnuson AM, Thurber GM, Kohler RH, Weissleder R, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1511-6 Epub 2015 Jan 20.

Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: Age, diet, and PPARγ effects.
Cipolletta D, Cohen P, Spiegelman BM, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):482-7

Genomic responses to inflammation in mouse models mimic humans: we concur, apples to oranges comparisons won't do.
Shay T, Lederer JA, Benoist C. Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E346.

2014 publications

 

Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells.
Fu W, Farache J, Clardy SM, Hattori K, Mander P, Lee K, Rioja I, Weissleder R, Prinjha RK, Benoist C, Mathis D. Elife. 2014 Nov 19;3.

 

Single-cell mass cytometry of TCR signaling: Amplification of small initial differences results in low ERK activation in NOD mice.
Mingueneau M, Krishnaswamy S, Spitzer MH, Bendall SC, Stone EL, Hedrick SM, Pe'er D, Mathis D, Nolan GP, Benoist C. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16466-71.

Variation and Genetic Control of Gene Expression in Primary Immunocytes across Inbred Mouse Strains.
Mostafavi S, Ortiz-Lopez A, Bogue MA, Hattori K, Pop C, Koller D, Mathis D, Benoist C; The Immunological Genome Consortium, Blair DA, Dustin ML, Shinton SA, Hardy RR, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Rao TN, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Best AJ, Knell J, Goldrath A, Jojic V, Koller D, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J5, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL. J Immunol. 2014 Nov 1;193(9):4485-96.

Intersection of population variation and autoimmunity genetics in human T cell activation.
Ye CJ, Feng T, Kwon HK, Raj T, Wilson MT, Asinovski N, McCabe C, Lee MH, Frohlich I, Paik HI, Zaitlen N, Hacohen N, Stranger B, De Jager P, Mathis D, Regev A, Benoist C. Science. 2014 Sep 12;345(6202):1254665.

Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature.
Stangenberg L, Burzyn D, Binstadt BA, Weissleder R, Mahmood U, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11419-24.

 

Type 1 Diabetes in NOD Mice Unaffected by Mast Cell Deficiency.
Gutierrez DA, Fu W, Schonefeldt S, Feyerabend TB, Ortiz-Lopez A, Lampi Y, Liston A, Mathis D, Rodewald HR. Diabetes. 2014 Jun 10.

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes.
Raj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, Feng T, Lee M, Asinovski N, Frohlich I, Imboywa S, Von Korff A, Okada Y, Patsopoulos NA, Davis S, McCabe C, Paik HI, Srivastava GP, Raychaudhuri S, Hafler DA, Koller D, Regev A, Hacohen N, Mathis D, Benoist C, Stranger BE, De Jager PL. Science. 2014 May 2;344(6183):519-523.

Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut.
Morton AM, Sefik E, Upadhyay R, Weissleder R, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2014 May 6;111(18):6696-701.

Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses.
Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, Kuchroo VK. Immunity. 2014 Apr 17;40(4):569-81.

Interindividual variation in human T regulatory cells.
Ferraro A, D'Alise AM, Raj T, Asinovski N, Phillips R, Ergun A, Replogle JM, Bernier A, Laffel L, Stranger BE, De Jager PL, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):E1111-20.

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch
Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM. Cell. 2014 Jan 16;156(1-2):304-16.

An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription.
Giraud M, Jmari N, Du L, Carallis F, Nieland TJ, Perez-Campo FM, Bensaude O, Root DE, Hacohen N, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1491-6.

Fluorescent Exendin-4 Derivatives for Pancreatic β-Cell Analysis.
Clardy SM, Keliher EJ, Mohan JF, Sebas M, Benoist C, Mathis D, Weissleder R. Bioconjug Chem. 2014 Jan 15;25(1):171-7

2013 publications

A special population of regulatory T cells potentiates muscle repair.
Burzyn D, Kuswanto W, Kolodin D, Shadrach JL, Cerletti M, Jang Y, Sefik E, Tan TG, Wagers AJ, Benoist C, Mathis D. Cell. 2013 Dec 5;155(6):1282-95.

Restoration of the Unfolded Protein Response in Pancreatic β Cells Protects Mice Against Type 1 Diabetes.
Engin F, Yermalovich A, Ngyuen T, Hummasti S, Fu W, Eizirik DL, Mathis D, Hotamisligil GS. Sci Transl Med. 2013 Nov 13;5(211):211ra156.

A gut feeling about arthritis.
Mathis D. Elife. 2013 Nov 5;2(0).

Soluble factors secreted by T-cells promote β-cell proliferation.
Dirice E, Kahraman S, Jiang W, El Ouaamari A, De Jesus DF, Teo AK, Hu J, Kawamori D, Gaglia JL, Mathis D, Kulkarni RN. Diabetes. 2014 Jan;63(1):188-202.

Regulatory T cells in nonlymphoid tissues.
Burzyn D, Benoist C, Mathis D. Nat Immunol. 2013 Oct;14(10):1007-13. Review

Differential Response of Regulatory and Conventional CD4+ Lymphocytes to CD3 Engagement: Clues to a Possible Mechanism of Anti-CD3 Action?
Li L, Nishio J, van Maurik A, Mathis D, Benoist C. J Immunol. 2013 Oct 1;191(7):3694-704

Immunological goings-on in visceral adipose tissue.
Mathis D. Cell Metab. 2013 Jun 4;17(6):851-9. Review.

 

Differential splicing across immune system lineages.
Ergun A, Doran G, Costello JC, Paik HH, Collins JJ, Mathis D, Benoist C; ImmGen Consortium. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14324-9.

 

Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2.
Sitrin J, Ring A, Garcia KC, Benoist C, Mathis D. J Exp Med. 2013 Jun 3;210(6):1153-65.

The transcriptional landscape of αβ T cell differentiation.
Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C; Immunological Genome Consortium. Nat Immunol. 2013 Jun;14(6):619-32.

Conservation and divergence in the transcriptional programs of the human and mouse immune systems.
Shay T, Jojic V, Zuk O, Rothamel K, Puyraimond-Zemmour D, Feng T, Wakamatsu E, Benoist C, Koller D, Regev A; ImmGen Consortium. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2946-51. Epub 2013 Feb 4.

Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance.
Yang S, Bansal K, Lopes J, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1833-8.

Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells.
Wakamatsu E, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):1023-8.

2012 publications

The immune system's involvement in obesity-driven type 2 diabetes.
Shu CJ, Benoist C, Mathis D.
Semin Immunol. 2012 Dec;24(6):436-42. Review.

Imputing gene expression from selectively reduced probe sets.
Donner Y, Feng T, Benoist C, Koller D. Nat Methods. 2012 Nov;9(11):1120-5. Epub 2012 Oct 14.

A common polymorphism near PER1 and the timing of human behavioral rhythms.
Lim AS, Chang AM, Shulman JM, Raj T, Chibnik LB, Cain SW, Rothamel K, Benoist C, Myers AJ, Czeisler CA, Buchman AS, Bennett DA, Duffy JF, Saper CB, De Jager PL.Ann Neurol. 2012 Sep;72(3):324-34.

Consortium biology in immunology: the perspective from the Immunological Genome Project.
Benoist C, Lanier L, Merad M, Mathis D; The Immunological Genome Project. Nat Rev Immunol. 2012 Oct;12(10):734-40. Epub 2012 Sep 7. Review.

Treg cells, life history, and diversity.
Mathis D, Benoist C. Cold Spring Harb perspect Biol. 2012 Sep 1;4(9). Review.

A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells.
Ergun A, Lu T, Hill JA, Haxhinasto S, Fassett MS, Gazit R, Adoro S, Glimcher L, Chan S, Kastner P, Rossi D, Collins JJ, Mathis D, Benoist C. Nat Immunol. 2012 Oct;13(10):972-80.

PPAR-g is a major driver of the accumulation and phenotype of adipose tissue Treg cells.
Cipolletta D, Feuerer M, Li A, Kamei N, Lee J, Shoelson SE, Benoist C, Mathis D. Nature. 2012 Jun 28;486(7404):549-53.

Gut immune maturation depends on colonization with a host-specific microbiota.
Chung H, Pamp SJ, Hill JA, Surana NK, Edelman SM, Troy EB, Reading NC, Villablanca EJ, Wang S, Mora JR, Umesaki Y, Mathis D, Benoist C, Relman DA, Kasper DL.
Cell. 2012 Jun 22;149(7):1578-93.

An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes.
Darce J, Rudra D, Li L, Nishio J, Cipolletta D, Rudensky AY, Mathis D, Benoist C.
Immunity. 2012 May 25;36(5):731-41.

Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging.
Fu W, Wojtkiewicz G, Weissleder R, Benoist C, Mathis D. Nat Immunol. 2012 Feb 26;13(4):361-8.

Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion.
Fassett MS, Jiang W, D'Alise AM, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3891-6.

Thymic negative selection is functional in NOD mice.
Mingueneau M, Jiang W, Feuerer M, Mathis D, Benoist C. J Exp Med. 2012 Mar 12;209(3):623-37.

The neuropeptide neuromedin U promotes autoantibody-mediated arthritis.
Rao SM, Auger JL, Gaillard P, Weissleder R, Wada E, Torres R, Kojima M, Benoist C, Mathis D, Binstadt BA. Arthritis Res Ther. 2012 Feb 7;14(1):R29.

Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells.
Giraud M, Yoshida H, Abramson J, Rahl PB, Young RA, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):535-40. Epub 2011 Dec 27

The influence of the microbiota on type-1 diabetes: on the threshold of a leap forward in our understanding.
Mathis D, Benoist C. Immunol Rev. 2012 Jan;245(1):239-49. Review.

2011 publications

Cre-Mediated Cell Ablation Contests Mast Cell Contribution in Models of Antibody- and T Cell-Mediated Autoimmunity.
Feyerabend TB, Weiser A, Tietz A, Stassen M, Harris N, Kopf M, Radermacher P, Möller P, Benoist C, Mathis D, Fehling HJ, Rodewald HR. Immunity. 2011 Nov 23;35(5):832-44.

Microbiota and autoimmune disease: the hosted self.
Mathis D, Benoist C. Cell Host Microbe. 2011 Oct 4;10(4):297-301. Review.

Accurate measurement of pancreatic islet {beta}-cell mass using a second-generation fluorescent exendin-4 analog.
Reiner T, Thurber G, Gaglia J, Vinegoni C, Liew CW, Upadhyay R, Kohler RH, Li L, Kulkarni RN, Benoist C, Mathis D, Weissleder R. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12815-20.

Tissular T(regs): A unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism.
Cipolletta D, Kolodin D, Benoist C, Mathis D. Semin Immunol. 2011 Dec;23(6):431-7. Review.

Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice.
Kriegel MA, Sefik E, Hill JA, Wu HJ, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11548-53.

Genome-Wide and Species-Wide Dissection of the Genetics of Arthritis Severity in Heterogeneous Stock Mice.
Johnsen AK, Valdar W, Golden L, Ortiz-Lopez A, Hitzemann R, Flint J, Mathis D, Benoist C. Arthritis Rheum. 2011 Sep;63(9):2630-40.

A cluster of coregulated genes determines TGF-{beta}-induced regulatory T-cell (Treg) dysfunction in NOD mice.
D'Alise AM, Ergun A, Hill JA, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8737-42.

Immunometabolism: an emerging frontier.
Mathis D, Shoelson SE. Nat Rev Immunol. 2011 Feb;11(2):81

Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells.
Bandukwala HS, Wu Y, Feuerer M, Chen Y, Barbosa B, Ghosh S, Stroud JC, Benoist C, Mathis D, Rao A, Chen L. 2011 Apr 22;34(4):479-91.

Transcriptomes of the B and T Lineages Compared by Multiplatform Microarray Profiling.
Painter MW, Davis S, Hardy RR, Mathis D, Benoist C; The Immunological Genome Project Consortium. J Immunol. 2011 Mar 1;186(5):3047-3057.

Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients.
Gaglia JL, Guimaraes AR, Harisinghani M, Turvey SE, Jackson R, Benoist C, Mathis D, Weissleder R. J Clin Invest. 2011 Jan 4;121(1):442-5.

2010 publications

The Type 1 Diabetes PhysioLab Platform: a validated physiologically based mathematical model of pathogenesis in the non-obese diabetic mouse..
HHuang GJ, Smith Shoda L, Kreuwel H, Gadkar K, Zheng Y, Whiting C, Atkinson M, Bluestone J, Mathis D, Young D and Ramanujan S. Clin Exp Immunol. 2010; 161:250-267.

A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus.
Huang GJ, Smith AL, Gray DH, Cosgrove C, Singer BH, Edwards A, Sim S, Parent JM, Johnsen A, Mott R, Mathis D, Klenerman P, Benoist C, Flint J. PLoS Biol. 2010 Dec 14;8(12):e1000561.

Stability of the Regulatory T Cell Lineage in vivo.
Yuri P. Rubtsov, Rachel E. Niec, Steven Josefowicz, Li Li, Jaime Darce, Diane Mathis, Christophe Benoist, and Alexander Y. Rudensky.Science. 2010 Sep 24;329(5999):1667-71.

Commercially available outbred mice for genome-wide association studies.
Yalcin B, Nicod J, Bhomra A, Davidson S, Cleak J, Farinelli L, Østerås M, Whitley A, Yuan W, Gan X, Goodson M, Klenerman P, Satpathy A, Mathis D, Benoist C, Adams DJ, Mott R, Flint J. PLoS Genet. 2010 Sep 2;6(9).

Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints.
Nishio J, Feuerer M, Wong J, Mathis D, Benoist C.J Exp Med. 2010 Aug 30;207(9):1879-89.

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells.
Wu HJ, Ivanov II, Darce J, Hattori K, Shima T, Umesaki Y, Littman DR, Benoist C, Mathis D. Immunity. 2010 Jun 25;32(6):815-827.

Global relevance of Aire binding to hypomethylated lysine-4 of histone-3.
Koh AS, Kingston RE, Benoist C, Mathis D.. 2010 Jul 20;107(29):13016-21.

Deficiency of CXCR2, but not other chemokine receptors, attenuates a murine model of autoantibody-mediated arthritis.
Jacobs JP, Ortiz-Lopez A, Campbell JJ, Gerard CJ, Mathis D, Benoist C. Arthritis Rheum. 2010 Jul;62(7):1921-32.

A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice.
Suwanai H, Wilcox MA, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9305-10.

Quantitative phosphoproteomic analysis of T cell receptor signaling in diabetes prone and resistant mice.
Iwai LK, Benoist C, Mathis D, White FM. J Proteome Res. 2010 Jun 4;9(6):3135-45.

Genomic definition of multiple ex vivo regulatory T cell subphenotypes.
Feuerer M, Hill JA, Kretschmer K, von Boehmer H, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5919-24. Epub 2010 Mar 15.

Neutrophils in a mouse model of autoantibody-mediated arthritis: Critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1.
Monach PA, Nigrovic PA, Hock H, Lee DM, Benoist C, Mathis D. Arthritis Rheum. 2010 Mar;62(3):753-64.

Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis.

Huang H, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4658-63. Epub 2010 Feb 22.

Aire's Partners in the Molecular Control of Immunological Tolerance. Abramson J, Giraud M, Benoist C, Mathis D.
Cell. 140(1):123-135, 8 January 2010.

Levees of immunological tolerance.
Mathis D, Benoist C. Nat Immunol. 2010 Jan;11(1):3-6 Review

.

2009 publications

IL-17-producing T cells can augment autoantibody-induced arthritis.
Jacobs JP, Wu HJ, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21789-94.

How Punctual Ablation of Regulatory T Cells Unleashes an Autoimmune Lesion within the Pancreatic Islets.
Feuerer M, Shen Y, Littman DR, Benoist C, Mathis D.Immunity<. 2009 Oct 16;31(4):654-64.

The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms.
Binstadt BA, Hebert JL, Ortiz-Lopez A, Bronson R, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16758-63.

A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis.
Monach PA, Hueber W, Kessler B, Tomooka BH, Benbarak M, Simmons BP, Wright J, Thornhill TS, Monestier M, Ploegh H, Robinson WH, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15867-72.

Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function.
Stangenberg L, Ellson C, Cortez-Retamozo V, Ortiz-Lopez A, Yuan H, Blois J, Smith RA, Yaffe MB, Weissleder R, Benoist C, Mathis D, Josephson L, Mahmood U. Arthritis Rheum. 2009 Jul 30;60(8):2314-2324.

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters.
Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, Lee J, Goldfine AB, Benoist C, Shoelson S, Mathis D. Nat Med. 2009 Aug;15(8):930-9.

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes.
Feuerer M, Hill JA, Mathis D, Benoist C. Nat Immunol. 2009 Jul;10(7):689-95. Review

Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity.
Guerau-de-Arellano M, Martinic M, Benoist C, Mathis D. J Exp Med. 2009 Jun 8;206(6):1245-52.

Autoimmune Diabetes. Diane Mathis and  Jason Gaglia.
From:  Molecular Imaging, by Ralph Weissleder, Brian D. Ross, Alnawaz Rehemtulla, Sanjiv Sam Gambhir. Pmph Usa; 1st  edition . April 30, 2009.

Aire.
Mathis D, Benoist C. Annu Rev Immunol. 2009;27:287-312. Review

2008 publications

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors.
D'Alise AM, Auyeung V, Feuerer M, Nishio J, Fontenot J, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19857-62.

Retinoic Acid Enhances Foxp3 Induction Indirectly by Relieving Inhibition from CD4(+)CD44(hi) Cells.
Hill JA, Hall JA, Sun CM, Cai Q, Ghyselinck N, Chambon P, Belkaid Y, Mathis D, Benoist C. Immunity. 2008 Nov;29(5):758-70.

Genetic Inversion in Mast Cell-Deficient Wsh Mice Interrupts Corin and Manifests as Hematopoietic and Cardiac Aberrancy.
Nigrovic PA, Gray DH, Jones T, Hallgren J, Kuo FC, Chaletzky B, Gurish M, Mathis D, Benoist C, Lee DM. Am J Pathol. 2008 Dec;173(6):1693-701.

Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.
Koh AS, Kuo AJ, Park SY, Cheung P, Abramson J, Bua D, Carney D, Shoelson SE, Gozani O, Kingston RE, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15878-83.

The variable immunological self: Genetic variation and nongenetic noise in Aire-regulated transcription.
Venanzi ES, Melamed R, Mathis D, Benoist C. Proc Natl Acad Sci USA. 2008 Oct14; 105(41) :15860-5.

Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated..
Villaseñor J, Besse W, Benoist C, Mathis D.Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15854-9.

The Immunological Genome Project: networks of gene expression in immune cells.
Heng TS, Painter MW; Immunological Genome Project Consortium. Nat Immunol. 2008 Oct;9(10):1091-4.

Transcriptional impact of Aire varies with cell type.
Guerau-de-Arellano M, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14011-6.

B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients.
Gavanescu I, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13009-14.

A broad analysis of IL1 polymorphism and rheumatoid arthritis.
Johnsen AK, Plenge RM, Butty V, Campbell C, Dieguez-Gonzalez R, Gomez-Reino JJ, Shadick N, Weinblatt M, Gonzalez A, Gregersen PK, Benoist C, Mathis D. Arthritis Rheum. 2008 Jun 24;58(7):1947-1957.

Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the DPT1 trial.
Butty V, Campbell C, Mathis D, Benoist C; the Diabetes Prevention Trial-Type 1 Study Group.2. Diabetes. 2008 Sep;57(9):2348-59.

The K/BxN Arthritis Model.
Monach PA, Mathis D, Benoist C. Curr Protoc Immunol. 2008 May;Chapter 15:Unit15.22.

The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells.
Haxhinasto S, Mathis D, Benoist C. J Exp Med. 2008 Mar 17;205(3):565-74.

 

2007 publications

Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature.
Hill JA, Feuerer M, Tash K, Haxhinasto S, Perez J, Melamed R, Mathis D, Benoist C. Immunity. 2007 Nov;27(5):786-800.

Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes.
Feuerer M, Jiang W, Holler PD, Satpathy A, Campbell C, Bogue M, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18181-18186.

Danger-free autoimmune disease in Aire-deficient mice.
Gray DH, Gavanescu I, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18193-18198.

Lymphotoxin Pathway and Aire Influences on Thymic Medullary Epithelial Cells Are Unconnected.
Venanzi ES, Gray DH, Benoist C, Mathis D. J Immunol. 2007 Nov 1;179(9):5693-5700.

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire.
Gray D, Abramson J, Benoist C, Mathis D. J Exp Med. 2007 Oct 29;204(11):2521-8.

Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation.
Obst R, van Santen HM, Melamed R, Kamphorst AO, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15460-5.

Circulating C3 is necessary and sufficient for induction of autoantibody-mediated arthritis in a mouse model.
Monach PA, Verschoor A, Jacobs JP, Carroll MC, Wagers AJ, Benoist C, Mathis D. Arthritis Rheum. 2007 Aug 30;56(9):2968-2974

The K/BxN mouse model of inflammatory arthritis: Theory and Practice.
Monach P, Hattori K, Huang H, Hyatt E, Morse J, Nguyen L, Ortiz-Lopez A, Wu HJ,Mathis D, and Benoist C. From: Methods in Molecular Medicine, Vol. 136, Arthritis Research, Volume2. Edited by A.P. Cope © Humana Press Inc., Totowa, NJ

TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets.
Wong J, Mathis D, Benoist C. J Exp Med. 2007 Sep 3;204(9):2039-45.

Inflammatory arthritis can be reined in by CpG-induced DC NK cell cross talk.
Wu HJ, Sawaya H, Binstadt B, Brickelmaier M, Blasius A, Gorelik L, Mahmood U, Weissleder R, Carulli J, Benoist C, Mathis D. J Exp Med. 2007 Aug 6;204(8):1911-1922.

A decade of AIRE.
Mathis D, Benoist C. Nat Rev Immunol.Aug;7(8):645-50.

Adaptation of TCR Repertoires to Self-Peptides in Regulatory and Nonregulatory CD4+ T Cells.
Wong J, Obst R, Correia-Neves M, Losyev G, Mathis D, Benoist C. J Immunol. 2007 Jun 1; 178(11):7032-7041.

The same genomic region conditions clonal deletion and clonal deviation to the CD8{alpha}{alpha} and regulatory T cell lineages in NOD versus C57BL/6 mice.
Holler PD, Yamagata T, Jiang W, Feuerer M, Benoist C, Mathis D.Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7187-92. Epub 2007 Apr 16.

Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity.
Gavanescu I, Kessler B, Ploegh H, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4583-7.

Lack of Foxp3 function and expression in the thymic epithelium.
Liston A, Farr AG, Chen Z, Benoist C, Mathis D, Manley NR, Rudensky AY. J Exp Med. 2007 Mar 19;204(3):475-80.

Regulatory T-cell differentiation: Committed to control: a precocious choice?
Haxhinasto S, Benoist C, Mathis D. Immunol Cell Biol. 2007 Apr;85(3):175-6.

Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1.
Nigrovic PA, Binstadt BA, Monach PA, Johnsen A, Gurish M, Iwakura Y, Benoist C, Mathis D, Lee DM. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2325-30.

Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis.
Nguyen LT, Jacobs J, Mathis D, Benoist C. Arthritis Rheum. 2007 Jan 30;56(2):509-520.

T(reg) cells: guardians for life.
Hill JA, Benoist C, Mathis D. Nat Immunol. 2007 Feb;8(2):124-125.

Altered natural killer cells in type 1 diabetic patients.
Rodacki M, Svoren B, Butty V, Besse W, Laffel L, Benoist C, Mathis D. Diabetes. 2007 Jan;56(1):177-85.

2006 publications

Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes.
Butty V, Roy M, Sabeti P, Besse W, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2006 Dec 29.

Modeling CTLA4-linked autoimmunity with RNA interference in mice.
Chen Z, Stockton J, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16400-5.

FOXP3 controls regulatory T cell function through cooperation with NFAT.
Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, Stroud JC, Bates DL, Guo L, Han A, Ziegler SF, Mathis D, Benoist C, Chen L, Rao A. Cell. 2006 Jul 28;126(2):375-87.

Gene expression microarrays: glimpses of the immunological genome.
Hyatt G, Melamed R, Park R, Seguritan R, Laplace C, Poirot L, Zucchelli S, Obst R, Matos M, Venanzi E, Goldrath A, Nguyen L , Luckey J, Yamagata T, Herman A, Jacobs J, Mathis D, Benoist C. Nat Immunol. 2006 Jul;7(7):686-91.

A plaidoyer for 'systems immunology'.
Benoist C, Germain RN, Mathis D. Immunol Rev. 2006 Apr;210:229-34.

A shared gene-expression signature in innate-like lymphocytes.
Yamagata T, Benoist C, Mathis D. Immunol Rev. 2006 Apr;210:52-66.

Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. Nishio J, Gaglia JL, Turvey SE, Campbell C, Benoist C, Mathis D. Science. 2006 Mar 24;311(5768):1775-8.

Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen.
Huang H, Kearney JF, Grusby MJ, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2006 Feb 27.

Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells.
Luckey CJ, Bhattacharya D, Goldrath AW, Weissman IL, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2006 Feb 2.

Particularities of the vasculature can promote the organ specificity of autoimmune attack.
Binstadt BA, Patel PR, Alencar H, Nigrovic PA, Lee DM, Mahmood U, Weissleder R, Mathis D, Benoist C. Nat Immunol. 2006 Mar;7(3):284-92.

...

2005 publications

 

Endocrine self and gut non-self intersect in the pancreatic lymph nodes.
Turley SJ, Lee JW, Dutton-Swain N, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17729-33. Epub 2005 Nov 29.

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes.
Chen Z, Herman AE, Matos M, Mathis D, Benoist C. J Exp Med. 2005 Nov 21;202(10):1387-97.

Cathepsin L is essential for onset of autoimmune diabetes in NOD mice.
Maehr R, Mintern JD, Herman AE, Lennon-Dumenil AM, Mathis D, Benoist C, Ploegh HL. J Clin Invest. 2005 Oct;115(10):2934-43. Epub 2005 Sep 22.

How defects in central tolerance impinge on a deficiency in regulatory T cells.
Chen Z, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14735-40. Epub 2005 Oct 3.

Modifier loci condition autoimmunity provoked by Aire deficiency.
Jiang W, Anderson MS, Bronson R, Mathis D, Benoist C. J Exp Med. 2005 Sep 19;202(6):805-15.

 

Lymphocyte tolerance: central is central.
Mathis D Harvey Lect. 2003-2004;99:95-110. Review

Variation in IL-1{beta} gene expression is a major determinant of genetic differences in arthritis aggressivity in mice.
Ohmura K, Johnsen A, Ortiz-Lopez A, Desany P, Roy M, Besse W, Rogus J, Bogue M, Puech A, Lathrop M, Mathis D, Benoist C. Proc Natl Acad Sci U S A. 2005 Aug 19.

 

The Cellular Mechanism of Aire Control of T Cell Tolerance.
Anderson MS, Venanzi ES, Chen Z, Berzins SP, Benoist C, Mathis D. Immunity. 2005 Aug;23(2):227-239.

Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes.
Turvey SE, Swart E, Denis MC, Mahmood U, Benoist C, Weissleder R, Mathis D. J Clin Invest. 2005 Aug 18;

Interleukin-4 can be a key positive regulator of inflammatory arthritis.
Ohmura K, Nguyen LT, Locksley RM, Mathis D, Benoist C. Arthritis Rheum. 2005 Jun 2;52(6):1866-1875

Antigen persistence is required throughout the expansion phase of a CD4+ T cell response.
Obst R, van Santen HM, Mathis D, Benoist C. J Exp Med. 2005 May 16;201(10):1555-65.

Chromosomal clustering of genes controlled by the aire transcription factor.
Johnnidis JB, Venanzi ES, Taxman DJ, Ting JP, Benoist CO, Mathis DJ.Proc Natl Acad Sci U S A. 2005 May 17;102(20):7233-8. Epub 2005 May 9.

 

AIRE and APECED: molecular insights into an autoimmune disease.
Villasenor J, Benoist C, Mathis D. Immunol Rev. 2005 Apr;204:156-64. Review

Defective Central Tolerance Induction in NOD Mice: Genomics and Genetics.
Zucchelli S, Holler P, Yamagata T, Roy M, Benoist C, Mathis D. Immunity. 2005 Mar;22(3):385-396.

Green t(r) cells.
Feuerer M, Benoist C, Mathis D. Immunity. 2005 Mar;22(3):271-2.

2004 publications

 

Back to central tolerance.
Mathis D, Benoist C. Immunity. 2004 May;20(5):50 9-16 Review

Good riddance: Thymocyte clonal deletion prevents autoimmunity.
Venanzi ES, Benoist C, Mathis D. Curr Opin Immunol. 2004 Apr;16(2):197-202.

 

Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells.
van Santen HM, Benoist C, Mathis D.J Exp Med. 2004 Nov 15;200(10):1221-30.

Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis.
Jacobs JP, Pettit AR, Shinohara ML, Jansson M, Cantor H, Gravallese EM, Mathis D, Benoist C. Arthritis Rheum. 2004 Aug;50(8):2685-94.

Fas deficiency prevents type 1 diabetes by inducing hyporesponsiveness in islet beta-cell-reactive T-cells.
Vence L, Benoist C, Mathis D. Diabetes. 2004 Nov;53(11):2797-803.

Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity.
Poirot L, Benoist C, Mathis D.Proc Natl Acad Sci U S A. 2004 May 25;101(21):8102-7. Epub 2004 May 12.

Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overview.
Matos M, Park R, Mathis D, Benoist C.Diabetes. 2004 Sep;53(9):2310-21.

Imaging inflammation of the pancreatic islets in type 1 diabetes.
Denis MC, Mahmood U, Benoist C, Mathis D, Weissleder R.Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12634-9. Epub 2004 Aug 10.

The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease.
Monach PA, Benoist C, Mathis D.Adv Immunol. 2004;82:217-48. Review.

Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells. Yamagata T, Mathis D, Benoist C.Nat Immunol. 2004 Jun;5(6):597-605.

CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion.
Herman AE, Freeman GJ, Mathis D, Benoist C. J Exp Med. 2004 Jun 7;199(11):1479-89.

The molecular program indued in T cells undergoing homeostatic proliferation.
Goldrath AW, Luckey JC, Park R, Benoist C, Mathis D Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16885-90.

2003 publications

Immunology at Asilomar: from molecules to mice.
Wilson CB, Uittenbogaart CH, Mathis DJ.Nat Immunol. 2003 Apr;4(4):300-2.

Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model.
Turley S, Poirot L, Hattori M, Benoist C, Mathis D.J Exp Med. 2003 Nov 17;198(10):1527-37.

aradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand.
Martin-Orozco N, Chen Z, Poirot L, Hyatt E, Chen A, Kanagawa O, Sharpe A, Mathis D, Benoist C. J Immunol. 2003 Dec 15;171(12):6954-60.

Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.
Stratmann T, Martin-Orozco N, Mallet-Designe V, Poirot L, McGavern D, Losyev G, Dobbs CM, Oldstone MB, Yoshida K, Kikutani H, Mathis D, Benoist C, Haskins K, Teyton L.J Clin Invest. 2003 Sep;112(6):902-14

T-cell compartments of prediabetic NOD mice.
Berzins SP, Venanzi ES, Benoist C, Mathis D.Diabetes. 2003 Feb;52(2):327-34.

Low prevalence of antibodies to glucose-6-phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders.
Matsumoto I, Lee DM, Goldbach-Mansky R, Sumida T, Hitchon CA, Schur PH, Anderson RJ, Coblyn JS, Weinblatt ME, Brenner M, Duclos B, Pasquali JL, El-Gabalawy H, Mathis D, Benoist C.Arthritis Rheum. 2003 Apr;48(4):944-54.

2002 publications

Mast cells in autoimmune disease.
Benoist C, Mathis D. Nature. 2002 Dec 19-26;420(6917):875-8.Review.

Projection of an immunological self shadow within the thymus by the aire protein.
Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ, von Boehmer H, Bronson R, Dierich A, Benoist C, Mathis.D. Science. 2002 Nov 15;298(5597):1395-401.

Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells.
Goldrath AW, Sivakumar PV, Glaccum M, Kennedy MK, Bevan MJ, Benoist C, Mathis D, Butz EA.J Exp Med. 2002 Jun 17;195(12):1515-22.

Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis.
Ji H, Pettit A, Ohmura K, Ortiz-Lopez A, Duchatelle V, Degott C, Gravallese E, Mathis D, Benoist C.J Exp Med. 2002 Jul 1;196(1):77-85.

How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease.
Matsumoto I, Maccioni M, Lee DM, Maurice M, Simmons B, Brenner M, Mathis D, Benoist C.Nat Immunol. 2002 Apr;3(4):360-5.

Arthritis critically dependent on innate immune system players
. Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, Duchatelle V, Degott C, Benoist C, Mathis D. Immunity. 2002 Feb;16(2):157-68.

 

Arthritogenic monoclonal antibodies from K/BxN mice.
Maccioni M, Zeder-Lutz G, Huang H, Ebel C, Gerber P, Hergueux J, Marchal P, Duchatelle V, Degott C, van Regenmortel M, Benoist C, Mathis D. J Exp Med. 2002 Apr 15;195(8):1071-7.

2001 publications

TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis.
Pettit AR, Ji H, von Stechow D, Muller R, Goldring SR, Choi Y, Benoist C, Gravallese EM. Am J Pathol. 2001 Nov;159(5):1689-99.

B-Cell Death During Progression to Diabetes.
Mathis D, Vence L; Benoist C. Nature. 2001 Dec 13;414(6865):792-8. Review

Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?
Benoist C, Mathis D. Nat Immunol. 2001 Sep;2(9):797-801.Review

Genetic influences on the end-stage effector phase of arthritis.
Ji H, Gauguier D, Ohmura K, Gonzalez A, Duchatelle V, Danoy P, Garchon HJ, Degott C, Lathrop M, Benoist C, Mathis D. J Exp Med. 2001 Aug 6;194(3):321-30

 

T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo.
Vivien L, Benoist C, Mathis D. Int Immunol. 2001 Jun;13(6):763-8.

Damage control, rather than unresponsivenesss, effected by protective DX5+ T cells in autoimmune diabetes.
Gonzalez A; Andre-Schmutz I; Carnaud C; Mathis D; Benoist C. Nat Immunol. 2001 Dec;2(12):1117-25.

How much TCR does a T cell need?
Labrecque N, Whitfield LS, Obst R, Waltzinger C, Benoist C, Mathis D. Immunity. 2001 Jul;15(1):71-82.

A molecular chart of thymocyte positive selection.
Correia-Neves M, Mathis D, Benoist C. Eur J Immunol. 2001 Sep;31(9):2583-92.

The shaping of the T cell repertoire.
Correia-Neves M, Waltzinger C, Mathis D, Benoist C. Immunity. 2001 Jan;14(1):21-32.

97-00 publications

A cassette vector for high-level reporter expression driven by a hybrid invariant chain promoter in transgenic mice.
van Santen H, Benoist C, Mathis D. J Immunol Methods. 2000 Nov 1;245(1-2):133-7.

A revival of the B cell paradigm for rheumatoid arthritis pathogenesis?
Benoist C, Mathis D. Arthritis Res. 2000;2(2):90-4. Review.

Role of the forkhead transcription family member, FKHR, in thymocyte differentiation.
Leenders H, Whiffield S, Benoist C, Mathis D.Eur J Immunol. 2000 Oct;30(10):2980-90.

 

Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells.
Luhder F, Chambers C, Allison JP, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12204-9.

Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules.
Witherden D, van Oers N, Waltzinger C, Weiss A, Benoist C, Mathis D. J Exp Med. 2000 Jan 17;191(2):355-64.

Mice lacking all conventional MHC class II genes.
Madsen L, Labrecque N, Engberg J, Dierich A, Svejgaard A, Benoist C, Mathis D, Fugger L Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10338-43.

Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme.
Matsumoto I, Staub A, Benoist C, Mathis D. Science. 1999 Nov 26;286(5445):1732-5.

The arthritogenic T cell receptor and its ligand in a model of spontaneous arthritis.
Mangialaio S, Ji H, Korganow AS, Kouskoff V, Benoist C, Mathis D. Arthritis Rheum. 1999 Dec;42(12):2517-23.

Different modes of pathogenesis in T-cell-dependent autoimmunity: clues from two TCR transgenic systems.
Ji H, Korganow AS, Mangialaio S, Hoglund P, Andre I, Luhder F, Gonzalez A, Poirot L, Benoist C, Mathis D. Immunol Rev. 1999 Jun;169:139-46. Review.

Amino acids specifying MHC class preference in TCR V alpha 2 regions.
Correia-Neves M, Waltzinger C, Wurtz JM, Benoist C, Mathis D. J Immunol. 1999 Nov 15;163(10):5471-7.

From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins.
Korganow AS, Ji H, Mangialaio S, Duchatelle V, Pelanda R, Martin T, Degott C, Kikutani H, Rajewsky K, Pasquali JL, Benoist C, Mathis D. Immunity. 1999 Apr;10(4):451-61.

T-cell development: a new marker of differentiation state.
Benoist C, Mathis D. Curr Biol. 1999 Jan 28;9(2):R59-61.

Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes.
Hoglund P, Mintern J, Waltzinger C, Heath W, Benoist C, Mathis D. J Exp Med. 1999 Jan 18;189(2):331-9.

pp

An influence of CD5 on the selection of CD4-lineage T cells. Chan S, Waltzinger C, Tarakhovsky A, Benoist C, Mathis D. Eur J Immunol. 1999 Sep;29(9):2916-22.

Cellular and molecular changes accompanying the progression from insulitis to diabetes.
Andre-Schmutz I, Hindelang C, Benoist C, Mathis D. Eur J Immunol. 1999 Jan;29(1):245-55.

Positive selection of thymocytes induced by gene transfer: MHC class II-mediated selection of CD8-lineage cells.
Rooke R, Waltzinger C, Benoist C, Mathis D. Int Immunol. 1999 Oct;11(10):1595-600.

Inhibition of thymocyte positive selection by natural MHC:peptide ligands.
Tourne S, Kouskoff V, Ho W, Davis M, Benoist C, Mathis D. Eur J Immunol. 1999 Feb;29(2):394-402.

Autoimmunity. The pathogen connection.
Benoist C, Mathis D.Nature. 1998 Jul 16;394(6690):227-8.

CD4/CD8 lineage commitment: matching fate with competence.
Chan S, Correia-Neves M, Benoist C, Mathis D. Immunol Rev. 1998 Oct;165:195-207. Review

CD4+ T cell responses in mice lacking MHC class II molecules specifically on B cells.
Williams GS, Oxenius A, Hengartner H, Benoist C, Mathis D. Eur J Immunol. 1998 Nov;28(11):3763-72.

Mice lacking the transcription factor CIITA--a second look.
Williams GS, Malin M, Vremec D, Chang CH, Boyd R, Benoist C, Mathis D. Int Immunol. 1998 Dec;10(12):1957-67.

Visualization of CD4/CD8 T cell commitment.
Chan S, Correia-Neves M, Dierich A, Benoist C, Mathis D. J Exp Med. 1998 Dec 21;188(12):2321-33.

Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities.
Luhder F, Katz J, Benoist C, Mathis D. Luhder F, Hoglund P, Allison JP, Benoist C, Mathis D. J Exp Med. 1998 Feb 2;187(3):379-87.

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes.
Luhder F, Hoglund P, Allison JP, Benoist C, Mathis D. J Exp Med. 1998 Feb 2;187(3):427-32.

Interleukin-4 deficiency does not exacerbate disease in NOD mice.
Wang B, Gonzalez A, Hoglund P, Katz JD, Benoist C, Mathis D. Diabetes. 1998 Aug;47(8):1207-11.

The phenotype of H-2M-deficient mice is dependent on the MHC class II molecules expressed. Wolf PR, Tourne S, Miyazaki T, Benoist C, Mathis D, Ploegh HL. Eur J Immunol. 1998 Sep;28(9):2605-18.

Autoimmune diabetes. Retrovirus as trigger, precipitator or marker?
Benoist C, Mathis D.Nature. 1997 Aug 28;388(6645):833-4.

Selection for survival?
Benoist C, Mathis D Science.1997 Jun 27;276(5321):2000-1

Cell death mediators in autoimmune diabetes--no shortage of suspects.
Benoist C, Mathis D. Cell. 1997 Apr 4;89(1):1-3. Review.

Positive selection of T cells: fastidious or promiscuous?
Benoist C, Mathis D. Curr Opin Immunol. 1997 Apr;9(2):245-9. Review.

Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes.
Wang B, Andre I, Gonzalez A, Katz JD, Aguet M, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13844-9.

Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses.
Rooke R, Waltzinger C, Benoist C, Mathis D.Immunity. 1997 Jul;7(1):123-34.

Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice.
Tourne S, Miyazaki T, Oxenius A, Klein L, Fehr T, Kyewski B, Benoist C, Mathis D. Immunity. 1997 Aug;7(2):187-95.

Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes.
Tourne S, Miyazaki T, Wolf P, Ploegh H, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9255-60.

 

Positive selection of T cells induced by viral delivery of neopeptides to the thymus.
Nakano N, Rooke R, Benoist C, Mathis D. Science. 1997 Jan 31;275(5300):678-83.

Genetic control of diabetes progression.
Gonzalez A, Katz JD, Mattei MG, Kikutani H, Benoist C, Mathis D. Immunity. 1997 Dec;7(6):873-83.

94-96 publications

Amino Acid residues on the I-Ak alpha-chain required for the binding and stability of two antigenic peptides.
Nelson CA, Viner N, Young S, Petzold S, Benoist C, Mathis D. J Immunol. 1996 Jan 1;156(1):176-82.

The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitus.
Wang B, Gonzalez A, Benoist C, Mathis D. Eur J Immunol. 1996 Aug;26(8):1762-9.

Checkpoints in the progression of autoimmune disease: lessons from diabetes models.
Andre I, Gonzalez A, Wang B, Katz J, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2260-3. Review.

Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway.
Miyazaki T, Wolf P, Tourne S, Waltzinger C, Dierich A, Barois N, Ploegh H, Benoist C, Mathis D. Cell. 1996 Feb 23;84(4):531-41.

The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation.
Wang B, Benoist C, Mathis D. J Exp Med. 1996 Jun 1;183(6):2427-36.

Independent modes of natural killing distinguished in mice lacking Lag3.
Miyazaki T, Dierich A, Benoist C, Mathis D. Science. 1996 Apr 19;272(5260):405-8.

LAG-3 is not responsible for selecting T helper cells in CD4-deficient mice.
Miyazaki T, Dierich A, Benoist C, Mathis D. Int Immunol. 1996 May;8(5):725-9.

Biosynthesis of major histocompatibility complex molecules and generation of T cells in Ii TAP1 double-mutant mice.
Tourne S, van Santen HM, van Roon M, Berns A, Benoist C, Mathis D, Ploegh H. Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1464-9.

Organ-specific disease provoked by systemic autoreactivity.
Kouskoff V, Korganow AS, Duchatelle V, Degott C, Benoist C, Mathis D. Cell. 1996 Nov 29;87(5):811-22.

Antiviral immune responses of mice lacking MHC class II or its associated invariant chain.
Battegay M, Bachmann MF, Burhkart C, Viville S, Benoist C, Mathis D, Hengartner H, Zinkernagel RM. Cell Immunol. 1996 Jan 10;167(1):115-21.

Mice lacking terminal deoxynucleotidyl transferase: adult mice with a fetal antigen receptor repertoire.
Gilfillan S, Benoist C, Mathis D. Immunol Rev. 1995 Dec;148:201-19. Review.

Efficient immune responses in mice lacking N-region diversity.
Gilfillan S, Bachmann M, Trembleau S, Adorini L, Kalinke U, Zinkernagel R, Benoist C, Mathis D. Eur J Immunol. 1995 Nov;25(11):3115-22.

The influence of invariant chain on the positive selection of single T cell receptor specificities.
Tourne S, Nakano N, Viville S, Benoist C, Mathis D. Eur J Immunol. 1995 Jul;25(7):1851-6.

Helper cell subsets in insulin-dependent diabetes.
Katz JD, Benoist C, Mathis D. Science. 1995 May 26;268(5214):1185-8.

CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice.
Cardell S, Tangri S, Chan S, Kronenberg M, Benoist C, Mathis D. J Exp Med. 1995 Oct 1;182(4):993-1004.

Cassette vectors directing expression of T cell receptor genes in transgenic mice.
Kouskoff V, Signorelli K, Benoist C, Mathis D. J Immunol Methods. 1995 Mar 27;180(2):273-80.

The influence of positive selection on RAG expression in thymocytes.
Kouskoff V, Vonesch JL, Benoist C, Mathis D. Eur J Immunol. 1995 Jan;25(1):54-8.

T-cell co-receptors. The end of a frustrating search.
Benoist C, Mathis D. Curr Biol. 1994 Sep 1;4(9):821-3. Review.

MHC control of the naive TCR alpha-chain repertoire. Merkenschlager M, Benoist C, Mathis D. J Immunol. 1994 Oct 1;153(7):3005-13.

Role of coreceptors in positive selection and lineage commitment.
Chan SH, Waltzinger C, Baron A, Benoist C, Mathis D. EMBO J. 1994 Oct 3;13(19):4482-9.

More efficient positive selection of thymocytes in mice lacking terminal deoxynucleotidyl transferase.
Gilfillan S, Waltzinger C, Benoist C, Mathis D. Int Immunol. 1994 Nov;6(11):1681-6.

Dominant negative analogs of NF-YA.
Mantovani R, Li XY, Pessara U, Hooft van Huisjduijnen R, Benoist C, Mathis D. J Biol Chem. 1994 Aug 12;269(32):20340-6.

In favor of the selective model of positive selection.
Chan SH, Benoist C, Mathis D. Semin Immunol. 1994 Aug;6(4):241-8. Review.

Evidence for a single-niche model of positive selection.
Merkenschlager M, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11694-8.

Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain. Bodmer H, Viville S, Benoist C, Mathis D. Science. 1994 Mar 4;263(5151):1284-6.

The immune system of mice lacking conventional MHC class II molecules.
Cardell S, Merkenschlager M, Bodmer H, Chan S, Cosgrove D, Benoist C, Mathis D. Adv Immunol. 1994;55:423-40. Review.

Graft rejection across transgene-encoded MHC class II molecules.
Rosay R, Hergueux J, Benoist C, Mathis D. C R Acad Sci III. 1994 Jul;317(7):639-43.

91-93 publications

Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice.
Katz J, Benoist C., Mathis D.
Eur J Immunol. 1993 Dec;23(12):3358-60.

Mice lacking TdT: mature animals with an immature lymphocyte repertoire.
Gilfillan S, Dierich A, Lemeur M, Benoist C, Mathis D. Science. 1993 Aug 27;261(5125):1175-8.

Transgenes and knock-outs in autoimmunity.
Benoist C, Mathis D. Curr Opin Immunol. 1993 Dec;5(6):900-2. Review>

A challenge to the instructive model of positive selection.
Chan SH, Benoist C, Mathis D. Immunol Rev. 1993 Oct;135:119-31. Review.

The virtue of complexity.
Benoist C, Mathis D. Curr Biol. 1993 Sep 1;3(9):625-7.

The immune system of mice lacking conventional MHC class II molecules.
Cardell S, Merkenschlager M, Bodmer H, Chan S, Cosgrove D, Benoist C, MathisD.

Graft rejection by Tcells not restricted by conventional major histo-compatibility complex molecules.
Dierich A, Chan SH, Benoist C, Mathis D. Eur J Immunol. 1993 Oct;23(10):2725-8.

Graft rejection across transgene-encoded MHC class II molecules.
Rosay R, Hergueux J, Benoist C, Mathis D

Following a diabetogenic T cell from genesis through pathogenesis.
Katz JD, Wang B, Haskins K, Benoist C, Mathis D. Cell. 1993 Sep 24;74(6):1089-100.

The level of N-region diversity in T cell receptors is not pre-ordained in the stem cell.
Bogue M, Mossmann H, Stauffer U, Benoist C, Mathis Eur J Immunol. 1993 May;23(5):1185-8.

Mice lacking the MHC class II-associated invariant chain.
Viville S, Neefjes J, Lotteau V, Dierich A, Lemeur M, Ploegh H, Benoist C, Mathis D. Cell. 1993 Feb 26;72(4):635-48.

 

The major histocompatibility complex (MHC) Ea promoter: sequences and factors at the initiation site.
Mantovani R, Tora L, Moncollin V, Egly JM, Benoist C, Mathis D. Nucleic Acids Res. 1993 Oct 25;21(21):4873-8.

Another view of the selective model of thymocyte selection.
Chan SH, Cosgrove D, Waltzinger C, Benoist C, Mathis D. Cell. 1993 Apr 23;73(2):225-36.

Knock-out mice: a new tool for transplantation immunologists.
Hergueux J, Bodmer H, Cardell S, Chan SH, Cosgrove D, Benoist C, Mathis D. Transplant Proc. 1993 Feb;25(1 Pt 1):30-2.Review.

Environmental modulation of the autonomy of cytotoxic T lymphocytes.
Bodmer H, Obert G, Chan S, Benoist C, Mathis D. Eur J Immunol. 1993 Jul;23(7):1649-54.

Regulation of N-region diversity in antigen receptors through thymocyte di-fferentiation and thymus ontogeny.
Bogue M, Gilfillan S, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):11011-5.

Structure of the TCR-Ag-MHC complex.
Gervois N, Wei BY, Dellabona P, Peccoud J, Benoist C, Mathis D

Monoclonal antibodies to NF-Y define its function in MHC class II and albumin gene transcription.
Mantovani R, Pessara U, Tronche F, Li XY, Knapp AM, Pasquali JL, Benoist C, Mathis D. EMBO J. 1992 Sep;11(9):3315-22.

Why is clonal deletion of neonatal thymocytes defective?
Signorelli K, Benoist C, Mathis D. Eur J Immunol. 1992 Oct;22(10):2487-93.

Generation of the alpha beta T-cell repertoire.
Benoist C, Mathis D. Curr Opin Immunol. 1992 Apr;4(2):156-61. Review.

 

A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice.
Kouskoff V, Fehling HJ, Lemeur M, Benoist C, Mathis D. J Immunol Methods. 1993 Dec 3;166(2):287-91.

Evolutionary variation of the CCAAT-binding transcription factor NF-Y.
Li XY, Mantovani R, Hooft van Huijsduijnen R, Andre I, Benoist C, Mathis D. Nucleic Acids Res. 1992 Mar 11;20(5):1087-91.

Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes.
Cosgrove D, Bodmer H, Bogue M, Benoist C, Mathis D. J Exp Med. 1992 Aug 1;176(2):629-34.

The thymic compartment responsible for positive selection of CD4+ T cells.
Cosgrove D, Chan SH, Waltzinger C, Benoist C, Mathis D. Int Immunol. 1992 Jun;4(6):707-10.

Mice lacking MHC class II molecules.
Cosgrove D, Gray D, Dierich A, Kaufman J, Lemeur M, Benoist C, Mathis D.Cell. 1991 Sep 6;66(5):1051-66.

Demystification of the alloresponse.
Benoist C, Mathis D. Curr Biol. 1991 Jun;1(3):143-4.

Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain.
Li XY, Hooft van Huijsduijnen R, Mantovani R, Benoist C, Mathis D. J Biol Chem. 1992 May 5;267(13):8984-90.

The V beta 17+ T cell repertoire: skewed J beta usage after thymic selection; dissimilar CDR3s in CD4+ versus CD8+ cells. Candeias S, Waltzinger C, Benoist C, Mathis D.
J Exp Med. 1991 Nov 1;174(5):989-1000.

One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes.
Li XY, Mattei MG, Zaleska-Rutczynska Z, Hooft van Huijsduijnen R, Figueroa F, Nadeau J, Benoist C, Mathis D. Genomics. 1991 Nov;11(3):630-4.

Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors.
Candeias S, Katz J, Benoist C, Mathis D, Haskins K. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6167-70.

A special repertoire of alpha:beta T cells in neonatal mice.
Bogue M, Candeias S, Benoist C, Mathis D. EMBO J. 1991 Dec;10(12):3647-54.

Local structure of a peptide contact site on Ak alpha.
Wei BY, Gervois N, Mer G, Adorini L, Benoist C, Mathis D. Int Immunol. 1991 Aug;3(8):833-7.

A single amino acid substitution in the Ak molecule fortuitously provokes an alloresponse.
Dellabona P, Wei BY, Gervois N, Benoist C, Mathis D.Eur J Immunol. 1991 Jan;21(1):209-13.

NF-X, a transcription factor implicated in MHC class II gene regulation.
Kouskoff V, Mantovani RM, Candeias SM, Dorn A, Staub A, Lisowska-Grospierre B, Griscelli C, Benoist CO, Mathis DJ. J Immunol. 1991 May 1;146(9):3197-204.

The E alpha promoter: A linker-scanning analysis.
Viville S, Jongeneel V, Mantovani R, Benoist C, Mathis D

 

88-90 publications

Defects in antigen presentation of mutant influenza haemagglutinins are reversed by mutations in the MHC class II molecule.
Warren AP, Paschedag I, Benoist C, Peccoud J, Mathis D, Thomas DB. EMBO J. 1990 Dec;9(12):3849-56.

Delineation of antigen contact residues on an MHC class II molecule
Peccoud J, Dellabona P, Allen P, Benoist C, Mathis D. EMBO J. 1990 Dec;9(13):4215-23.

Co-evolution from yeast to mouse: cDNA cloning of NF-Y subunits.
Hooft van Huijsduijnen R, Li XY, Black D, Benoist C, Mathis D. EMBO J. 1990 Oct;9(10):3119-27.

MHC-linked protection from diabetes dissociated from clonal deletion of T cells.
Bohme J, Schuhbaur B, Kanagawa O, Benoist C, Mathis D.Science. 1990 Jul 20;249(4966):293-5.

   

Regulation of MHC class II gene expression: the Y box and the nuclear factor that binds to it, NF-Y.
Hooft van Huijsdjuinen R, Xiao-Yan L, Mantovani R, Benoist C, Mathis D.

 

Regulation of major histocompatibility complex class-II genes: X, Y and other letters of the alphabet.
Benoist C, Mathis D. Annu Rev Immunol. 1990;8:681-715. Review

 

Superantigens interact with MHC class II molecules outside the antigen groove.
Dellabona P, Peccoud J, Kappler J, Marrack P, Benoist C, Mathis D. Cell. 1990 Sep 21;62(6):1115-21.

 

Functional consequences of overexpressed Ia antigens in Akalpha/Akbeta transgenic mice.
Fehling HJ, van Ewijk W, Pasquali JL, Waltzinger C, Lemeur M, Gerlinger P, Benoist C, Mathis D. J Immunol. 1990 Apr 15;144(8):2865-74.

Sperm cells as vectors for transferring DNA into mouse eggs: a breakthrough for immunologists?
Benoist C, Mathis D. Immunol Today. 1989 Nov;10(11):369.

T-cell recognition of superantigens: inside or outside the groove?
Dellabona P, Peccoud J, Benoist C, Mathis D. Cold Spring Harb Symp Quant Biol. 1989;54 Pt 1:375-81.

 

Positive and negative selection of the T cell reperoire in MHC class II transgenic mice.
Benoist C, Mathis D. Semin Immunol. 1989 Nov;1(2):117-24. Review.>

 

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.
Berg LJ, Pullen AM, Fazekas de St Groth B, Mathis D, Benoist C, Davis MM. Cell. 1989 Sep 22;58(6):1035-46.

Positive selection of the T cell repertoire: where and when does it occur?
Benoist C, Mathis D. Cell. 1989 Sep 22;58(6):1027-33.

85-87 publications

Transgenic mice: new systems for studying the function of MHC class II molecules. In "H-2 antigens: genes, molecules and function."
Lang G; Gerber P; Bohme J; Burand B; Felhing J; LeMeur M; Marfing C; Benoist C; Mathis D.

Properties of a CCAAT box-binding protein.
Hooft van Huijsduijnen RA, Bollekens J, Dorn A, Benoist C, Mathis D. Nucleic Acids Res. 1987 Sep 25;15(18):7265-82.

A multiplicity of CCAAT box-binding proteins.
Dorn A, Bollekens J, Staub A, Benoist C, Mathis D. Cell. 1987 Sep 11;50(6):863-72.

Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins.

Dorn A, Durand B, Marfing C, Le Meur M, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 1987 Sep;84(17):6249-53

The regulation of Ia gene transcription.
Gerber P, Dorn A, Durand B, Lemeur M, Gerlinger P, Benoist C, Mathis D.

Functional sites on Ia molecules: a molecular dissection of A alpha immunogenicity.
Landais D, Waltzinger C, Beck BN, Staub A, McKean DJ, Benoist C, Mathis D.Cell. 1986 Oct 24;47(2):173-81.

 

The assignment of chain specificities for anti-Ia monoclonal antibodies using L cell transfectants.
LandaisD, Beck BN, Buerstedde JM, Degraw S, Klein D, Koch N, Murphy D, Pierres M, Tada T, Yamamoto K, et al. J Immunol. 1986 Nov 1;137(9):3002-5.

Altered I-J phenotype in E alpha transgenic mice.
Flood PM, Benoist C, Mathis D, Murphy DB.Proc Natl Acad Sci U S A. 1986 Nov;83(21):8308-12.

 

E alpha u and E beta u chain association: where lies the anomaly?
Ayane M, Mengle-Gaw L, McDevitt HO, Benoist C, Mathis D.J Immunol. 1986 Aug 1;137(3):948-51.

 

Transgenic mice: "New Wave" immunogenetics.
Benoist C; Gerlinger P; LeMeur M and Mathis D

 

Correcting an immune-response deficiency by creating E alpha gene transgenic mice.
Le Meur M, Gerlinger P, Benoist C, Mathis D. Nature. 1985 Jul 4-10;316(6023):38-42.

 

A molecular basis for the Ia.2 and Ia.19 antigenic determinants.
Landais D, Matthes H, Benoist C, Mathis D.Proc Natl Acad Sci U S A. 1985 May;82(9):2930-4.

Inbred and wild mice carry identical deletions in their E alpha MHC genes.
Dembic Z, Ayane M, Klein J, Steinmetz M, Benoist CO, Mathis DJ.EMBO J. 1985 Jan;4(1):127-31