CBDM Lab Journal Club



Presented by


June 4 , 2024

Jayashree Vijaya Raghavan

Heart failure promotes multimorbidity through innate immune memory
Nakayama et al
Sci Immunol. 2024 May 24;9(95):eade3814.doi: 10.1126/sciimmunol.ade3814. Epub 2024 May 24.
May 21 , 2024

Brooke Huisman

Xist ribonucleoproteins promote female sex-biased autoimmunity
Dou et al
Cell. Volume 187, Issue 3, 1 February 2024, Pages 733-749.e16
May 14 , 2024

Adelaide Gelineau

Type I interferons induce an epigenetically distinct memory B cell subset in chronic viral infection
Cooper et al
Immunity. 2024 Mar 29:S1074-7613(24)00137-7. doi: 10.1016/j.immuni.2024.03.016. Online ahead of print.
April 23 , 2024

Chong Zuo

Immune microniches shape intestinal Treg function
Gu et al
Nature. 2024 Apr 3. doi: 10.1038/s41586-024-07251-0.
April 9 , 2024

Xinxin Chi

Neutrophil profiling illuminates anti-tumor antigen-presenting potency
Wu et al
Cell.2024 Mar 14;187(6):1422-1439.e24.doi: 10.1016/j.cell.2024.02.005. Epub 2024 Mar 5.
March 12, 2024

Nathan Zammit

IL-23 stabilizes an effector Treg cell program in the tumor microenvironment
Wertheimer et al
Nature Immunology volume 25, pages 512–524 (2024)
March 5, 2024

Yangyang Zhu

Maternal inflammation regulates fetal emergency myelopoiesis.
Collins et al
Feb 27, 2024

Yutao Wang

Complement in Breast Milk Modifies Offspring Gut Microbiota to Promote Infant Health.
Dongqing et al
Cell 187 (3): 750–63.e20.
Feb 6, 2024

Silvia Galvan-Pena

CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus
Elsherif Badr et al
Science . 2023 Nov 3;382(6670):534-541. doi: 10.1126/science.adh4124. Epub 2023 Nov 2.
Jan 23, 2024

Gang Wang

A type 1 immunity-restricted promoter of the IL−33 receptor gene directs antiviral T-cell responses.
Brunner et al
Nat Immunol . 2024 Jan 3. doi: 10.1038/s41590-023-01697-6. Online ahead of print.
Jan 9, 2024

Andres Munoz-Rojas

Exocrine gland–resident memory CD8+ T cells use mechanosensing for tissue surveillance", by , at Journal Club.
Ruef et al
Sci Immunol. 2023 Dec 22;8(90):eadd5724. doi: 10.1126/sciimmunol.add5724. Epub 2023 Dec 22.
Nov 21, 2023

Kent Langston

Immunomodulatory leptin receptor+ sympathetic perineurial barrier cells protect against obesity by facilitating brown adipose tissue thermogenesis.
Haberman et al
Immunity. 2023 Dec 5:S1074-7613(23)00488-0. doi: 10.1016/j.immuni.2023.11.006.
Nov 21, 2023

Kumba Seddu

Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines against SARS-CoV-2 BA.5 infection in nonhuman primates.
Routhu et al
Sci. Immunol. 8, eadg7015 (2023) 27 October 2023
Nov 14, 2023 Yuan Fang
Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice.
Zhang et al
Nature. 2023 Sep;621(7977):196-205. doi: 10.1038/s41586-023-06463-0. Epub 2023 Aug 23.
Oct 17, 2023 Miguel Marin Rodero
Lymphatic endothelial transcription factor Tbx1 promotes an immunosuppressive microenvironment to facilitate post-myocardial infarction repair
Wang et al
Immunity. 2023 Oct 10;56(10):2342-2357.e10. doi: 10.1016/j.immuni.2023.07.019. Epub 2023 Aug 24.
May 23, 2023 Sylvia Galvan-Pena
Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment
Bender et al
Cell. Volume 186, Issue 9, 27 April 2023, Pages 1846-1862.e26
Apr 25, 2023 Kent Langston
Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis
Wculek et al
Immunity. 2023 Mar 14;56(3):516-530.e9. doi: 10.1016/j.immuni.2023.01.011. Epub 2023 Feb 3.
Apr 25, 2023 Gang Wang
Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection
Sikder et al
Immunity 56, 1–17 May 9, 2023 https://doi.org/10.1016/j.immuni.2023.03.002
Apr 11, 2023 Adelaide Gelineau
Host-versus-commensal immune responses participate in the rejection of colonized solid organ transplants
Pirozzolo et al
J Clin Invest. 2022;132(17):e153403.
Apr 4, 2023 Bola Hanna
Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis
Jeyanathan et al
Nature Immunology 23, pages 1687–1702 (2022)
Mar 28, 2023 David Owen
IFNγ binding to extracellular matrix prevents fatal systemic toxicity
Kemna et al
Nature Immunology,volume 24 pages414–422 (2023)
Mar 21, 2023 Andres Munoz-Rojas
Monocytes re-enter the bone marrow during fasting and alter the host response to infection
Janssen et al
Immunity (2023), https://doi.org/10.1016/j.immuni.2023.01.024
Mar 7, 2023 Yangyang Zhu
Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer
Zagorulya et al
Immunity. 2023 Feb 14;56(2):386-405.e10. doi: 10.1016/j.immuni.2023.01.010. Epub 2023 Feb 2.
Feb 28, 2023 Yutao Wang
Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation
Chen et al
Immunity. 2023 Feb 14;56(2):336-352.e9. doi: 10.1016/j.immuni.2023.01.015.
Feb 7, 2023 Chong Zhu
Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS
Pallet et al
Nature (2023). https://doi.org/10.1038/s41586-022-05645-6
Jan 31, 2023 Kait Chowdhary
Functional T cells are capable of supernumerary cell division and longevity
Soerens et al
Nature. 2023 Jan 18. doi: 10.1038/s41586-022-05626-9. Online ahead of print.
Jan 24, 2023 Nathan Zammit
Active eosinophils regulate host defense and immune responses in colitis
Gurtner et al
Nature (2022). https://doi-org.ezp-prod1.hul.harvard.edu/10.1038/s41586-022-05628-7
Jan 10, 2023 Xinxin Chi
Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer
Sinha et al
Cell. 2022 Dec 8;185(25):4717-4736.e25. doi: 10.1016/j.cell.2022.11.004.
Dec 13, 2022 Brooke Huisman
Divergent clonal differentiation trajectories of T cell exhaustion
Daniel et al
Nature Immunology volume 23, pages1614–1627 (2022)
Dec 6, 2022 Miguel Marin Rodero
T cells specific for α-myosin drive immunotherapy-related myocarditis
Axelrod et al
Nature volume 611, pages 818–826 (2022).
Nov 22, 2022 Yuan Fang
Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes
Wang et al
Science. 2022 Jul 15;377(6603):292-297. doi: 10.1126/science.abn3100. Epub 2022 Jul 14.
Oct 25, 2022 Dan Michelson
Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality
Sano et et al
Science. 2022 Jul 15;377(6603):292-297. doi: 10.1126/science.abn3100. Epub 2022 Jul 14.
Oct 18, 2022 Tesh Jaywickreme
Innate type 2 immunity controls hair follicle commensalism by Demodex mites.
Ricardo-Gonzalez et al
Immunity. 2022 Oct 11;55(10):1891-1908.e12. doi: 10.1016/j.immuni.2022.08.001.
May 24, 2022 Nathan Zammit
Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus
Shinzawa et al
Nature Immunology volume 23, pages 731–742 (2022)
May 17, 2022 Yangyang Zhu
Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine.
Xiong et al
Immunity. 2022 Apr 12;55(4):686-700.e7. doi: 10.1016/j.immuni.2022.03.001. Epub 2022 Mar 22.
April 19, 2022 Mi Lian
Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches
Dähling et al
Immunity. 2022 Mar 30;S1074-7613(22)00129-7. doi:10.1016/j.immuni.2022.03.006.
April 12, 2022 Gang Wang
Anatomically distinct fibroblast subsets determine skin autoimmune patterns.
Xu et al,
Nature volume 601, pages 118–124 (2022)
March 29, 2022 Andres Munoz-Rojas
Normality sensing licenses local T cells for innate-like tissue surveillance
McKinzie et al,
Nat Immunol . 2022 Mar;23(3):411-422. Epub 2022 Feb 14.
March 22, 2022 Silvia Galvan-Pena
The lung microbiome regulates brain autoimmunity
Hosang et al,
Nature. 2022 Mar;603(7899):138-144. Epub 2022 Feb 23.
March 8, 2022 Martina Sassone Corsi
Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation
Cautivo et al,
Immunity. 2022. 55, 254–271
Feb 22, 2022 Bola Hanna
Marginal zone B cells acquire dendritic cell functions by trogocytosis
Schriek et al
SCIENCE • 11 Feb 2022 • Vol 375, Issue 6581
Feb 8, 2022 Deepshika Ramanan
Clonally Expanded B Cells in Multiple Sclerosis Bind EBV EBNA1 and GlialCAM
Lanz et al
Nature . 2022 Jan 24. doi: 10.1038/s41586-022-04432-7.
Feb 1st, 2022 Juliette Leon
CAR T cells produced in vivo to treat cardiac injury
Rurik et al
Science. 2022 Jan 7;375(6576):91-96. doi: 10.1126/science.abm0594. Epub 2022 Jan 6.
Jan 25, 2022 Yuan Fang
Jpx RNA regulates CTCF anchor site selection and formation of chromosome loops
Oh et al 
Cell. 2021 Dec 9;184(25):6157-6173.e24.
Jan 11, 2022 Miguel Marin-Rodero
Infant T cells are developmentally adapted for robust lung immune responses through enhanced T cell receptor signaling.
Thapa et al
Sci Immunol. 2021 Dec 10;6(66):eabj0789. Epub 2021 Dec 10
Dec 14, 2021 Kait Chowdhary
Insular cortex neurons encode and retrieve specific immune responses
Koren et al
Cell. Volume 184, Issue 24, 24 November 2021, Pages 5902-5915.e17
Nov 30, 2021 Omar Yaghi
The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock
Brooks et al
Cell 184, 4154–4167
Nov 9, 2021 Tesh Jaywickreme
Early-life inflammation primes a T helper 2 cell–fibroblast niche in skin.
Boothby et al
Nature. 2021 Oct 27. doi: 10.1038/s41586-021-04044-7.
Oct 26, 2021 Dan Michelson
Early developing B cells undergo negative selection by central nervous system-specific antigens in the meninges.
Wang et al
Immunity. 2021 Oct 1;S1074-7613(21)00401-5.
Oct 12, 2021 Tianli Xiao
Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion.
Choa et al
Science. 2021 Jul 30;373(6554):eabd2893.
Nov 10, 2020 Juliette Leon
Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung
Faustino et al
Nat Immunol 21, 1371–1383 (2020).
Nov 3, 2020 Deepshika Ramanan
Sex differences in immune responses that underlie COVID-19 disease outcomes
Takahashi et al
Nature . 2020 Aug 26. doi: 10.1038/s41586-020-2700-3.
Oct 27, 2020 Kent Langston
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion
Yu et al
Nat Immunol. 2020 Oct 5. doi: 10.1038/s41590-020-0793-3.
Oct 13, 2020 Yiqing Yan
Microbiota-derived metabolite promotes HDAC3 activity in the gut
Wu et al
Nature. 2020 Oct;586(7827):108-112. doi: 10.1038/s41586-020-2604-2. Epub 2020 Jul 30.
Oct 6, 2020 Andres Munoz-Rojas
A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart.
Nicolas-Avila et al
Cell. 2020 Sep 15;S0092-8674(20)31073-4.
Sept 29, 2020 Martina Sassone Corsi
Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts
Crespo et al
Cell. 2020 Sep 3;182(5):1125-1139.e18. Epub 2020 Aug 20.
Sept 22, 2020 Yuan Fang
Spt5-mediated enhancer transcription directly couples enhancer activation with physical promoter interaction
Fitz et al
Nat Genet. 2020 May;52(5):505-515. Epub 2020 Apr 6.
Sept 8, 2020 Bola Hanna
Senolytic CAR T cells reverse senescence-associated pathologies
Amor et al
Nature. 2020 Jul;583(7814):127-132. doi: 10.1038/s41586-020-2403-9. Epub 2020 Jun 17.
Sept 1st, 2020 Ricardo Ramirez
Global reference mapping of human transcription factor footprints
Vierstra et al
Nature. 2020 Jul;583(7818):729-736. doi: 10.1038/s41586-020-2528-x. Epub 2020 Jul 29
Au 25, 2020 Silvia Galvan-Pena
Microglia require CD4 T cells to complete the fetal-to-adult transition
Emanuela Pasciuto et al
Cell. 2020 Aug 6;182(3):625-640.e24.
Augt 11, 2020 Raul German Spallanzani
Resident memory CD8 T cells persist for years in human small intestine
Bartolome-Casado et al
J Exp Med. 2019 Oct 7;216(10):2412-2426. .
August 4, 2020 Yutao Wang
Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis
Seidman et al
Immunity. 2020 Jun 16;52(6):1057-1074.e7. doi: 10.1016/j.immuni.2020.04.001. Epub 2020 May 1.
Jul 28, 2020 Payam Zarin
Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity.
Liu et al
Nat Immunol. 2020 Jul 13.doi: 10.1038/s41590-020-0733-2. Online ahead of print..
Ju 21, 2020 Alexander Mann
An mRNA Vaccine against SARS-CoV-2 —Preliminary Report
Jackson et al
N Engl J Med. 2020 Jul 14. Online ahead of print.
Mar 10, 2020 Miguel Marin Rodero
Sex-specific adipose tissue imprinting of regulatory T cells.
Vasanthakumar et al
Nature. 2020 Feb 26. doi: 10.1038/s41586-020-2040-3. [Epub ahead of print]
Mar 3, 2020 Kaitavjeet Chowdhary
VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours.
Song et al
Nature volume 577, pages689–694(2020)
Feb 11, 2020 Daniel Michelson
MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota.
Koyama et al
Immunity. 2019 Nov 19;51(5):885-898.e7.
Feb 11, 2020 Teshika Jaywickreme
Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells
Zhang et al
Nature. 2020 Jan;577(7792):676-681. Epub 2020 Jan 22.
Feb 4, 2020 Tianli Xiao
Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity
Jarret et al.
Cell. 2020 Jan 9;180(1):50-63.e12.
Jan 14, 2020 Omar Yaghi
Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses
Nagai et al.
Cell. 2019 Aug 22;178(5):1072-1087.e14.
Jan 14, 2020 Omar Yaghi
Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses
Nagai et al.
Cell. 2019 Aug 22;178(5):1072-1087.e14.
May 28, 2019 Miguel Marin-Rodero
Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming.
Schneider et al.
Immunity, 50. 1-14 June 18, 2019.
May 14, 2019 Tesh Jaywickreme
Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.
Schmidleithner et al
Immunity. 2019 Apr 15. pii: S1074-7613(19)30131-1. doi: 10.1016/j.immuni.2019.03.014. [Epub ahead of print]
Apr 30, 2019 Omar Yaghi
Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion
Leyva-Castillo et al
Immunity. 2019 50, 1–14 DOI:https://doi.org/10.1016/j.immuni.2019.03.023
Apr 23, 2019 Tianli Xiao
Compartmentalized gut lymph node drainage dictates adaptive immune responses Esterházy et al
Esterházy et al
Nature. 2019 Apr 15. doi: 10.1038/s41586-019-1125-3. [Epub ahead of print]
Apr 9, 2019 Alexander Mann
Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States Wei et al
Wei et al
Immunity. 2019 Mar 22. pii: S1074-7613(19)30094-9. doi: 10.1016/j.immuni.2019.03.004. [Epub ahead of print]
Apr 2, 2019 German Spallanzani
Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches
Chakarov et al
Science. 2019 Mar 15;363(6432). pii: eaau0964. doi: 10.1126/science.aau0964.
Mar 26, 2019 Andres Munoz Rojas
Sleep modulates haematopoiesis and protects against atherosclerosis.
McAlpine et al
Nature. 2019 Feb;566(7744):383-387. Epub 2019 Feb 13.
Mar 19, 2019 Silvia Galvan-Pena
Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease
He et al
Nature volume 566, pages 115-119 (2019).
Mar 12, 2019 Evgeny Kiner
Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction
Liu, et al
Nature. 2019 Feb 27. doi: 10.1038/s41586-019-0979-8.
Feb 26, 2019 Payam Zarin
S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense
Huang et al
Science. 2018 Jan 5;359(6371):114-119.
Feb 12, 2019 Bola Hanna
Interleukin-22 protects intestinal stem cells against genotoxic stress
Gronke et al
Nature. 2019 Jan 30. doi: 10.1038/s41586-019-0899-7.
Feb 5, 2019 Yiqing Yan
A defined commensal consortium elicits CD8 T cells and anti-cancer immunity
Tanoue et al
Nature. 2019 Jan 23. doi: 10.1038/s41586-019-0878-z
Jan 29, 2019 Ricardo Ramirez
Genomic encoding of transcriptional burst kinetics
Larsson et al
Nature. 2019 Jan;565(7738):251-254. doi: 10.1038/s41586-018-0836-1. Epub 2019 Jan 2.
Jan 22, 2019 Deepshika Ramanan
Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells
Akkaya et al
Nat Immunol. 2019 Jan 14. doi: 10.1038/s41590-018-0280-2. [Epub ahead of print]
Jan 8, 2019 Jun Cho
High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes.
Croote D et al
Science. 2018 Dec 14;362(6420):1306-1309. doi: 10.1126/science.aau2599.
Dec 18, 2018 Martina Sassone- Corsi
Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury
Harrison, OJ, et al
Science 06 Dec 2018: eaat6280 DOI: 10.1126/science.aat6280
Dec 11, 2018 Jonatan Tuncel
Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response

Marcus et al

Immunity. 2018 Oct 16;49(4):754-763.e4. doi: 10.1016/j.immuni.2018.09.016.
Dec 4, 2018 Yanbo Zhang
T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation
Biton et al
Cell. 2018 Nov 15;175(5):1307-1320.e22. doi: 10.1016/j.cell.2018.10.008. Epub 2018 Nov 1.
Nov 27, 2018 Alvin Pratama
Microglial control of astrocytes in response to microbial metabolites
Rothhammer et al
Nature. 2018 May;557(7707):724-728. doi: 10.1038/s41586-018-0119-x. Epub 2018 May 16.
Nov 20, 2018 Chaoran Li
T cells in patients with narcolepsy target sef-antigens of hypocretin neurons
Latorre et al
Nature. 2018 Oct;562(7725):63-68. doi: 10.1038/s41586-018-0540-1. Epub 2018 Sep 19.