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Our Research

Autoimmune (type-1) diabetes

Autoimmune (type-1) diabetes reflects the specific destruction of insulin-producing beta cells in the pancreas due to T cell-mediated autoimmune attack. We study: genetics and proteomics of central tolerance in NOD mice; the roles of innate and adaptive immune-system cell-types, such as Tregs, NK cells and myeloid –derived regulatory cells; environmental and metabolic events that trigger the onset of insulitis and its eventual progression to overt diabetes; how costimulatory molecules control autoimmunity; how the gut microbiota influences diabetes development; the mechanism of action of therapeutic drug candidates, such as anti-CD3 or other immune modulators. In collaboration with colleagues at Mass General Hospital, we have also developed methods to image pancreatic inflammation non-invasively, initially in mice and now in human patients; methods to image beta-cell mass are also under development.
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Regulatory T cells (Treg)

Regulatory T cells (Treg) expressing the FoxP3 transcription factor are a fascinating cell population which have a profound impact on self-tolerance and homeostasis in the immune system. We analyze how they interact with other cells or microbes, how they vary between human individuals and how this may influence disease or cancer, how their transcriptional phenotypes are determined. We have found that Treg cells are also involved in a variety of mechanisms beyond immunological tolerance, for instance controlling adipocytes and metabolic parameters, or muscle regeneration after injury. We are probing these unusual pathways and their specificity.
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Interactions between the gut microbiome and the immune system

Interactions between the gut microbiome and the immune system remain enigmatic. Studies in the K/BxN mouse model of arthritis or in NOD mice address where and how the gut microbiome impacts on these disease models. More generally, we have begun broader explorations of the interaction between host genetics and microbiome composition and activity, and how different microbes influence the phenotype and traffic of key populations of the immune system.
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Aire

Aire is a transcriptional regulator that is critical for induction of central tolerance, through the unique mechanism of inducing the ectopic expression in the thymus of genes normally active in specialized tissue cells such as the brain or pancreas. Our foci are: molecular mechanisms of ectopic gene expression, including Aire’s protein partners; the cellular mechanisms though which this central tolerance is acquired and propagated; roles of innate and adaptive immune system cells in the autoimmune disease of Aire-deficient individuals; ontogeny of Aire-controlled tolerance.
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Immunological Genome project

The lab is also an active participant in ImmGen, a collaborative group of immunology and computational biology laboratories aiming to decipher very broadly the patterns and regulation of gene expression in the immune system.
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People Behind the CBDM Lab


Staff

Please note: At least one of the facts stated below is true. Others may or may not be...

"The planet does not need a large number of "successful people". The planet desperately needs peacekeepers, healers, restorers, storytellers and lovers of all kinds. She needs people next to whom to live well. The planet needs people with morality who are ready to join the struggle to make the world alive and humane. And these qualities have little in common with "success", as it is defined in our society."
-The Dalai Lama

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Natasha Asinosvski

I met Beyonce when I was nine.

I won a food eating contest in Minneapolis.

My favorite color is purple.

Here's a piece of Art I like

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Eunice Esomonu




Former dreamer

Current planner

Future surgeon.

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Sara Haidermota

I have 6 kids.

I have a BA in psychology.

I have been living in the US longer than I’ve lived in Japan.

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Kimie Hattori

For fun, I jumped out of an airplane three times.

I attended a mit-mit on Yap, known for its stone money, large doughnut-shaped, carved disks of calcite, up to 12ft used as legal tender.

I performed as part of a choral group at the Grand Ole Opry in Nashville when I was 10 years old.

Art I like: Hudson River School painting, Kindred Spirits by Asher Brown Durand

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Irene Kolada


Never bought sugar
Co-founded a community chorus.
I love beer.

I might have been in a NY state of mind, but after passing through my kind of town all I can say is, “Well I love that dirty water / Oh, Boston, you're my home”

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Larry Kozinn

I communicate with friends via transatlantic bottled messages.

I used to be a Lindy Hop danser.

I create Miro-style animated doodles (and it's addictive...)

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Catherine Laplace

I have been to flying trapeze school.
I have piloted a plane.

I used to be half of an accordion duet.

I'm a fan of Robert Burns, the national poet of my homeland, and I have often thought this line "The best laid schemes o' mice an' men / Gang aft agley"("The best laid schemes of mice and men / Go often askew") from "To a mouse", applies to research...

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Angela Magnuson

Sometimes I feel homesick and just hear this song.

This is my first year in CBDM lab.

I love working with mice.

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Adriana Ortiz-Lopez

I love gummy bears.

I wrote an award winning poem titled “Mon Cher Papa”.

I ice skate every year.

One of my all-time favorite mantras

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Kumba Seddu

I play both Indian and Western violin.

I have accidentally climbed a mountain (as in, kept walking without realizing I was climbing a mountain).

I am a decent calligrapher and have done calligraphy for multiple friends’ wedding invitations.

Artwork I like: Simon Beck, mathematical snow art

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Brinda Vijaykumar

I love NE Patriots and Houston Rockets.

I’ve once read 100 books in one year.

One of my favorite food is donkey meat.

Favorite painting: The Scream,1893, by Edvard Munch

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Liang Yang


Students & Post-doctoral fellows

Please note: At least one of the facts stated below is true. Others may or may not be...
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Jun Cho

I’m a bhangra and stand-up comedy enthusiast(usually not simultaneously.

Ike is my Super Smash Bros character of choice.

I play the euphonium.

Artwork I like

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Kaitavjeet Chowdhary

I have featured in a TV ad.

I speak five languages.

I was in a dancing hip hop crew.

Artwork I enjoy

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Silvia Galvan-Pena

I'm a die-hard Liverpool fan since age 4.It should be understood that Man United, Chelsea and especially Real Madrid fans should err on the side of caution around me.
I was part of a theater team for 15 years and once won a playwright award.
I had lunch with Angela Merkel at the German Chancellery.
I can write and speak Egyptian hieroglyphs.
A piece of art that I like: Give me the flute and sing (Song by Fairuz, lyrics by Kahlil Gibran)

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Bola Hanna

I love podcasts so much that I even hosted one.

I once qualified for the Boston Marathon but was too ill to compete.

I tried a hot sauce rated 3,000,000 scoville...for breakfast.

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Teshika Jayewickreme

Prior to science, my dream was to become a historian and be a tour guide.

I slid down from a fuming volcano on my butt.

I visited 39 countries.

A paniting I like

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Evgeny Kiner

I have hunted with falcons in the past.

I bought a 90 gallons fish tank by mistake and I had to carefully distribute the weight to avoid breaking the floor of the apartment.

I'm terrified of dancing.

A piece of art that I like

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Miguel Marin Rodero

Obama follows me on Twitter.

My hometown replaced all its streetlights with roundabouts.
vI have the most helpful review of Cheerios on Amazon.com.

An art piece I like: El Aleph -- Jorge Luis Borges

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Daniel Michelson

Loves sports especially basketball.

Father of two kids.

Likes playing video games.

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Chaoran Li

I had to learn to sing a song about my home state in elementary school.

I have won an eating contest.

I like to wear hats.

Favorite song: The Sound of Silence

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Alexander Mann

I was born and raised in Mexico City.

I am allergic to cats.

I am left-handed.

Favorite song: Simple Twist of Fate by Bob Dylan

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Andres Munoz-Rojas

I am a member of a “Batman villains” cosplay group.

I was a contestant on Masterchef Indonesia.

I once sat two rows behind Kevin Rudd (former Australian Prime Minister) in a movie theatre.

I was the President of Photography Society in college.

Favorite song: "Defying gravity"

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Alvin Pratama

I can speak 5 languages.

My favorite pastime is going to gym.

I eat a pint of ice-cream every night.

"Joy in looking and comprehending is nature's most beautiful gift"- Albert Einstein Pictured: Pangong Tso, Indo-China Border.

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Deepshika Ramanan

I was a lead guitarist in a technical metal and jazz/fusion band.

I make my own yogurt.

I enjoy ice skating.

Favorite song this is a favorite song of mine.

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Ricardo Ramirez

I love camping and mountain biking.

My family owns the best pastry shop in Naples.

I am a professional guitar player.

Favorite song: "Across the Universe", The Beatles

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Martina Sassone Corsi

I've been playing handball for 12 years at a semi-pro level.

I jumped by parachute once, greatest experience of my life.

I have a racing car but I prefer my bike.

Favorite song

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Hugo Schmutz

When younger, I studied music and graduated as professor but I never taught classes.

I always wanted to become an astronaut.

My favorite Marvel’s superhero is Daredevil.

Favorite song

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German Spallanzani
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Jonatan Tuncel

I once bumped into the UN secretary general randomly in the street.

I can solve a rubics cube in 8 seconds.

Favorite song

 
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Tianli Xiao

I am a big fan of pizza, especially because my family owns a small pizzeria business.
I was on Barcelona’s youth soccer team but eventually decided to pursue science and medicine instead of soccer.
I use to have an afro when I was younger.

A book that inspires me

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Omar Yaghi

If I am not working, I am traveling.

I have a Qipao collection.

I have a lipstick collection to go with my Qipao.

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Yiqing Yan

Prior to discovering immunology, I aspired to be a deep sea diver a la Jacques Cousteau.

I lived with an 86 year old roommate during my time in New York City.

"La porte de l'invisible doit être visible" is a good motto to follow in science.

An inspiration

 
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Payam Zarin

I have run 143 marathons in distance by Jan, 2019.

I like cooking as much as doing experiments.

I like eating as much as analyzing experimental data.

A song recently liked

 
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Yanbo Zhang

Our Resources

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ImmGen

The ImmGen website displays the results of gene expression expression across the immune system. It reports basic expression patterns, and meta-analyses (co-expression networks and clusters, signatures).

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Bioinformatic tools

A collection of programs & modules developed in this lab by Scott Davis in either R, Java or MATLAB for the analysis of microarray gene expression.
They are all designed to work with the same input file format: a GenePattern Expression Dataset (*.gct). All of these programs can be installed as GenePattern modules, though some of them can also be run as stand-alone Java applications. They include : ExpressCluster, Population PCA, GCT Extractor, ExpressMatrix, δ-Score, ExtractProbes, ClassMeans.

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Mouse models

The laboratory carries and distributes a number of transgenic/KO mouse lines of relevance to Type-1 Diabetes research.

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Protocols

Mouse procedures & Sample collection


Feel Free to Contact Us

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Department of Immunology
Harvard Medical School
77 Avenue Louis Pasteur
NRB 10th floor
Boston, MA 02115

Larry Kozinn
Administrative coordinator
Larry_Kozinn@hms.harvard.edu

Irene Kolada
Administrative assistant
Irene_Kolada@hms.harvard.edu

 

Tel: 617-432-7741

Fax: 617-432-7744